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Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Gene Name: | dickkopf WNT signaling pathway inhibitor 2 |
Synonyms: | DKK2, DKK-2, Dickkopf homolog 2, Dickkopf related protein-2, HDkk-2, Dickkopf-2, Dickkopf-related protein 2 |
Target Sequences: | NM_014421 NP_055236.1 Q9UBU2 |
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