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DKK1

dickkopf WNT signaling pathway inhibitor 1

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Gene Name: dickkopf WNT signaling pathway inhibitor 1
Synonyms: DKK1, Dickkopf-1 like, DKK-1, Dickkopf-1, Dickkopf-related protein 1, Dickkopf related protein-1, HDkk-1, Hdkk1, Dickkopf-like protein 1, SK
Target Sequences: NM_012242 NP_036374.1 O94907

Publications (7)

1
Dickkopf-1 is oncogenic and involved in invasive growth in non small cell lung cancer. Li S, Qin X, Guo X, Cui A, He Y, Wei S, Wang X, Shan B. PloS one. 2014 8:e84944. (WB; Human) [Full Text Article] [PubMed:24391982] [PMC:PMC3877398] Related Antibodies: LS-C201644.
2
Molecular Characterization of Microtubule Affinity-Regulating Kinase4 from Sus scrofa and Promotion of Lipogenesis in Primary Porcine Placental Trophoblasts. Tian L, Wen A, Dong S, Yan P. International journal of molecular sciences. 2019 March;20:pii E1206. [Full Text Article] [PubMed:30857324] [PMC:PMC6429113] Related Antibodies: LS-B194.
3
Development of a micro-tissue-mediated injectable bone tissue engineering strategy for large segmental bone defect treatment. Wu D, Wang Z, Wang J, Geng Y, Zhang Z, Li Y, Li Q, Zheng Z, Cao Y, Zhang ZY. Stem cell research & therapy. 2018 November;9:331. [Full Text Article] [PubMed:30486863] [PMC:PMC6263540] Related Antibodies: LS-C47394.
4
Differential expression of Dickkopf-1 among non-small cell lung cancer cells. Xiang XJ, Liu YW, Chen DD, Yu S. Molecular medicine reports. 2015 August;12:1935-1940. [Full Text Article] [PubMed:25901391] Related Antibodies: LS-A2867.
5
Maternal obesity stimulates lipotoxicity and up-regulates inflammatory signaling pathways in the full-term swine placenta. Tian Liang, Xie Jinglong, Dong Shusheng, Wen Aiyou. Animal science journal = Nihon chikusan Gakkaiho. 2018 September;89:1310-1322. [Full Text Article] [PubMed:29947166] Related Antibodies: LS-B194.
6
Nitric oxide production upregulates Wnt/ beta -catenin signaling by inhibiting Dickkopf-1. Du Q, Zhang X, Liu Q, Zhang X, Bartels CE, Geller DA. Cancer research. 2013 Nov;73:6526-37. [Full Text Article] [PubMed:24008318] [PMC:PMC3818363] Related Antibodies: LS-A2867.
7
Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma. Hirata H, Hinoda Y, Nakajima K, Kawamoto K, Kikuno N, Ueno K, Yamamura S, Zaman MS, Khatri G, Chen Y, Saini S, Majid S, Deng G, Ishii N, Dahiya R. International journal of cancer. Journal international du cancer. 2011 Apr;128:1793-803. [Full Text Article] [PubMed:20549706] Related Antibodies: LS-A2867.
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Antibodies (97)
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DKK1 Antibody - Human Uterus, Endometrium: Formalin-Fixed, Paraffin-Embedded (FFPE)
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DKK1 Rabbit anti-Human Polyclonal (Internal Region) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µg/$440
DKK1 Antibody - Anti-DKK1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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DKK1 Goat anti-Human Polyclonal (aa250-262) Antibody
Mouse, Goat, Dog, Bovine, Pig, Horse, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
DKK1 Antibody - Anti-DKK1 antibody IHC of human uterus, endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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DKK1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Pig, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
DKK1 Antibody - Western blot analysis of HepG2 cell lysate.
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DKK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
DKK1 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$612
DKK1 Antibody - Western blot of human DKK1 in A549 cell lysate in the 1) absence and 2) presence of immunizing peptide, and 3) RAW using antibody at 1 ug/ml.
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DKK1 Rabbit anti-Human Polyclonal (aa150-200) Antibody
Rabbit, Mouse, Human
WB
Unconjugated
100 µg/$386
DKK1 Antibody - Western blot of Human PANC1. DKK1 antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DKK1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
DKK1 Antibody - Western blot of Human PANC1. DKK1 antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DKK1 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Chicken, Zebrafish, Pig, Horse, Bat, Rat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Orangutan, Chimpanzee
WB
FITC Conjugated
100 µl/$469
DKK1 Antibody - Anti-DKK1 antibody IHC of human uterus, endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
DKK1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
DKK1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
DKK1 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
46.9 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$795
DKK1 Antibody - Western blot using DKK1 mouse monoclonal antibody against HEK293 (1) and DKK1-hIgGFc transfected HEK293 cell lysate (2).
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DKK1 Mouse anti-Human Monoclonal (2H2) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$403
DKK1 Antibody - DKK1 monoclonal antibody (M11), clone 2A5 Western blot of DKK1 expression in U-2 OS.
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DKK1 Mouse anti-Human Monoclonal (2A5) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
DKK1 Antibody - Western Blot; Sample: Rat Placenta Tissue.
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DKK1 Mouse anti-Human Monoclonal (Biotin) Antibody
Mouse, Human
WB
Biotin Conjugated
100 µl/$314; 200 µl/$359; 500 µl/$506; 1 ml/$580; 2 ml/$797; 5 ml/$1,295
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DKK1 Sheep anti-Rat Polyclonal Antibody
Rat
ELISA, WB
Unconjugated
100 µg/$930
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DKK1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
WB
Unconjugated
50 µg/$553; 100 µg/$820
DKK1 Antibody - Western blot analysis of extracts of HeLa cells.
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DKK1 Rabbit anti-Human Polyclonal (aa71-266) Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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DKK1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
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DKK1 Rabbit anti-Human Monoclonal (Preservative Free) (R015) Antibody
Human
Neut
Unconjugated, Preservative Free
200 µg/$398; 500 µg/$511
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HEK 293 Cells
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
35-40 kDa
2 µg/$268; 10 µg/$349
DKK1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
DKK1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
DKK1 Antibody - Anti-DKK1 antibody IHC of human uterus, endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
DKK1 Rabbit anti-Human Polyclonal (Internal) Antibody
Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
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DKK1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
100 µl/$412
DKK1 Antibody - Anti-DKK1 Antibody at 1:1000 dilution + HepG2 whole cell lysates Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 29 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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DKK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
400 µl/$393
Viewing 1-25 of 147 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).