DISC1

Disrupted in Schizophrenia 1

Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.

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Proteins (16)

Type

Over-Expression Lysate (12)

Recombinant (4)

Target

DISC1 (16)

Publications

No (16)

Tag

His-T7 (3)

Myc-DDK (Flag) (13)

Species

Human (8)

Mouse (1)

Rat (1)

Source

293T Cells (6)

E. coli (3)

HEK 293 Cells (7)

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DISC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G128087

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.1 kDa

Price:

100 µg/$494

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DISC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G128126

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.2 kDa

Price:

100 µg/$494

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DISC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G128218

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.7 kDa

Price:

100 µg/$494

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DISC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G128222

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.1 kDa

Price:

100 µg/$494

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DISC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G128309

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.1 kDa

Price:

100 µg/$710

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Mouse DISC1 Protein (Recombinant His-T7) (aa151-330) - LS-G24729

Source:

E. coli

Tag:

His-T7

Molecular Weight:

22.5 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human DISC1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72098

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

93.4 kDa

Price:

20 µg/$1,107

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Human DISC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91405

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.1 kDa

Price:

20 µg/$215

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Human DISC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91406

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.1 kDa

Price:

20 µg/$150

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Human DISC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91409

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.1 kDa

Price:

20 µg/$150

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Human DISC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91407

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.7 kDa

Price:

20 µg/$150

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Human DISC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91408

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.2 kDa

Price:

20 µg/$150

Select

Human DISC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91410

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

93.4 kDa

Price:

20 µg/$215

Select

DISC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101585

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

93.4 kDa

Price:

100 µg/$710

Select

Human DISC1 Protein (Recombinant His-T7) (aa102-261) - LS-G14863

Source:

E. coli

Tag:

His-T7

Molecular Weight:

20.2 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Rat DISC1 Protein (Recombinant His-T7) (aa151-340) - LS-G14865

Source:

E. coli

Tag:

His-T7

Molecular Weight:

24.1 kDa

Price:

10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257

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