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Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.
Gene Name: | DIS3 mitotic control homolog (S. cerevisiae)-like |
Synonyms: | DIS3L, DIS3-like exonuclease 1, DIS3L1, KIAA1955 |
Target Sequences: | NM_001143688 NP_001137160.1 Q8TF46 |
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