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DIO3

deiodinase, iodothyronine, type III

The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.

Gene Name: deiodinase, iodothyronine, type III
Synonyms: DIO3, 5DIII, D3, DIOIII, ITDI3, TXDI3, Type-III 5 deiodinase, Type-III 5-deiodinase, Type 3 DI
Target Sequences: NM_001362

Publications (5)

1
Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells. Freitas BC, Gereben B, Castillo M, Kall I, Zeld A, Egri P, Liposits Z, Zavacki AM, Maciel RM, Jo S, Singru P, Sanchez E, Lechan RM, Bianco AC. The Journal of clinical investigation. 2010 120:2206-17. [PubMed:20458138] [PMC:PMC2877954]
2
Contributions of HIV infection in the hypothalamus and substance abuse/use to HPT dysregulation. Langford D, Baron D, Joy J, Del Valle L, Shack J. Psychoneuroendocrinology. 2011 36:710-9. (ICC, IHC, WB; Human) [PubMed:21115295] [PMC:PMC3090485]
3
Candidate placental biomarkers for intrauterine alcohol exposure. Shukla PK, Sittig LJ, Ullmann TM, Redei EE. Alcoholism, clinical and experimental research. 2011 35:559-65. (WB; Rat) [PubMed:21143252] [PMC:PMC3117908]
4
A novel pathway regulates thyroid hormone availability in rat and human hypothalamic neurosecretory neurons. Kall I, Mohcsik P, Vida B, Zeld A, Bardczi Z, Zavacki AM, Farkas E, Kdr A, Hrabovszky E, Arrojo E Drigo R, Dong L, Barna L, Palkovits M, Borsay BA, Herczeg L, Lechan RM, Bianco AC, Liposits Z, Fekete C, Gereben B. PloS one. 2012 7:e37860. (IHC, WB; Human, Rat) [PubMed:22719854] [PMC:PMC3377717]
5
Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism. Jo S, Kall I, Bardczi Z, Arrojo e Drigo R, Zeld A, Liposits Z, Oliva A, Lemmon VP, Bixby JL, Gereben B, Bianco AC. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 32:8491-500. (IHC, WB; Human, Rat, Hamster) [PubMed:22723689]
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DIO3 ELISA Kit
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Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
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Rat
0.313 - 20 ng/ml
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Mouse
Colorimetric - 450nm (TMB)
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Pig
Colorimetric - 450nm (TMB)
1 Plate/$669
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96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$669
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
DIO3 ELISA Kit
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Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$783
DIO3 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
DIO3 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$748
DIO3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).