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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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DIO3

deiodinase, iodothyronine, type III

The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.

Gene Name: deiodinase, iodothyronine, type III
Synonyms: DIO3, 5DIII, D3, DIOIII, ITDI3, TXDI3, Type-III 5 deiodinase, Type-III 5-deiodinase, Type 3 DI
Target Sequences: NM_001362

Publications (5)

1
Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells. Freitas BC, Gereben B, Castillo M, Kall I, Zeld A, Egri P, Liposits Z, Zavacki AM, Maciel RM, Jo S, Singru P, Sanchez E, Lechan RM, Bianco AC. The Journal of clinical investigation. 2010 120:2206-17. [PubMed:20458138] [PMC:PMC2877954]
2
Contributions of HIV infection in the hypothalamus and substance abuse/use to HPT dysregulation. Langford D, Baron D, Joy J, Del Valle L, Shack J. Psychoneuroendocrinology. 2011 36:710-9. (ICC, IHC, WB; Human) [PubMed:21115295] [PMC:PMC3090485]
3
Candidate placental biomarkers for intrauterine alcohol exposure. Shukla PK, Sittig LJ, Ullmann TM, Redei EE. Alcoholism, clinical and experimental research. 2011 35:559-65. (WB; Rat) [PubMed:21143252] [PMC:PMC3117908]
4
A novel pathway regulates thyroid hormone availability in rat and human hypothalamic neurosecretory neurons. Kall I, Mohcsik P, Vida B, Zeld A, Bardczi Z, Zavacki AM, Farkas E, Kdr A, Hrabovszky E, Arrojo E Drigo R, Dong L, Barna L, Palkovits M, Borsay BA, Herczeg L, Lechan RM, Bianco AC, Liposits Z, Fekete C, Gereben B. PloS one. 2012 7:e37860. (IHC, WB; Human, Rat) [PubMed:22719854] [PMC:PMC3377717]
5
Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism. Jo S, Kall I, Bardczi Z, Arrojo e Drigo R, Zeld A, Liposits Z, Oliva A, Lemmon VP, Bixby JL, Gereben B, Bianco AC. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 32:8491-500. (IHC, WB; Human, Rat, Hamster) [PubMed:22723689]
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Filtered By: None
Target
DIO3 (43)
Reactivity
Human (18)
Mouse (9)
Rat (27)
Hamster (3)
Rabbit (1)
Application
IHC (17)
IHC-P (1)
WB (39)
ELISA (16)
ICC (2)
IF (1)
Peptide-ELISA (1)
Host
rabbit (43)
Isotype
IgG (31)
Clonality
polyclonal pc (43)
Format
AP Conjugated (1)
APC (1)
APC Conjugated (2)
Biotin Conjugated (8)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
DY488 Conjugated (2)
DY550 Conjugated (2)
DY650 Conjugated (2)
FITC Conjugated (6)
HRP Conjugated (4)
PE Conjugated (2)
Unconjugated (12)
Epitope
aa11-277 (13)
Internal (11)
aa250-278 (8)
aa37-278 (4)
aa1-100 (1)
aa17-66 (1)
Publications
No (43)
Showing 1-25 of 43 results

DIO3 Antibody (aa250-278) LS-C320845
Rabbit Polyclonal (IgG) to Human DIO3
Human
ELISA IHC WB
Unconjugated
200µl  $530.00

DIO3 Antibody (aa250-278, HRP) LS-C540410
Rabbit Polyclonal (IgG) to Human DIO3
Human
ELISA IHC WB
HRP Conjugated
200µl  $680.00

DIO3 Antibody (aa250-278, Biotin) LS-C520220
Rabbit Polyclonal (IgG) to Human DIO3
Human
ELISA IHC WB
Biotin Conjugated
200µl  $680.00

DIO3 Antibody (aa250-278, FITC) LS-C256119
Rabbit Polyclonal (IgG) to Human DIO3
Human
ELISA IHC WB
FITC Conjugated
200µl  $680.00

DIO3 Antibody (aa250-278, PE) LS-C256120
Rabbit Polyclonal (IgG) to Human DIO3
Human
ELISA IHC WB
PE Conjugated
200µl  $680.00

DIO3 Antibody (aa250-278, AP) LS-C256117
Rabbit Polyclonal (IgG) to Human DIO3
Human
ELISA IHC WB
AP Conjugated
200µl  $680.00

DIO3 Antibody (aa250-278, APC) LS-C256118
Rabbit Polyclonal (IgG) to Human DIO3
Human
ELISA IHC WB
APC Conjugated
200µl  $680.00

DIO3 Antibody (aa250-278) LS-C167418
Rabbit Polyclonal to Human DIO3
Human
IHC IHC-P WB
Unconjugated
400µl  $305.00
Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with DIO3 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of DIO3 Antibody in HepG2 cell line lysates (35 ug/lane). DIO3 (arrow) was detected using the purified antibody.
Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with DIO3 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of DIO3 Antibody in HepG2 cell line lysates (35 ug/lane). DIO3 (arrow) was detected using the purified antibody.

DIO3 Antibody LS-C677671
Rabbit Polyclonal (IgG) to Human DIO3
Human
ELISA IF
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunofluorescent analysis of PC3 cells diluted at 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Immunofluorescent analysis of PC3 cells diluted at 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

DIO3 Antibody LS-C409084
Rabbit Polyclonal (IgG) to Human DIO3
Human
IHC WB
Unconjugated
50µl  $255.00; 100µl  $315.00; 200µl  $425.00
Western blot analysis of extracts of various cells.
Western blot analysis of extracts of various cells.

DIO3 Antibody (aa11-277) LS-C314988
Rabbit Polyclonal (IgG) to Mouse DIO3
Mouse
WB
Unconjugated
100µl 0.5mg/ml  $355.00
Western blot of recombinant DIO3.
Western blot of recombinant DIO3.

DIO3 Antibody (aa11-277, Biotin) LS-C424031
Rabbit Polyclonal (IgG) to Mouse DIO3
Mouse
ICC WB
Biotin Conjugated
100µl 0.5mg/ml  $375.00

DIO3 Antibody (aa11-277, FITC) LS-C424033
Rabbit Polyclonal (IgG) to Mouse DIO3
Mouse
ICC WB
FITC Conjugated
100µl 0.5mg/ml  $395.00

DIO3 Antibody (Internal) LS-C383145
Rabbit Polyclonal (IgG) to Human DIO3
Mouse, Rat, Human
ELISA WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of DIO3 antibody
Western blot of DIO3 antibody

DIO3 Antibody (aa11-277) LS-C293665
Rabbit Polyclonal (IgG) to Rat DIO3
Rat
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $265.00; 200µl 0.5mg/ml  $315.00; 1ml 0.5mg/ml  $575.00; 10ml 0.5mg/ml  $2,280.00
Western blot of recombinant DIO3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant DIO3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

DIO3 Antibody (aa11-277, HRP) LS-C713519
Rabbit Polyclonal (IgG) to Rat DIO3
Rat
IHC WB
HRP Conjugated
20µl  $215.00; 100µl  $295.00; 200µl  $355.00; 1ml  $740.00; 10ml  $2,955.00
Western blot of recombinant DIO3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant DIO3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

DIO3 Antibody (aa11-277, Biotin) LS-C688663
Rabbit Polyclonal (IgG) to Rat DIO3
Rat
IHC WB
Biotin Conjugated
20µl  $215.00; 100µl  $275.00; 200µl  $325.00; 1ml  $620.00; 10ml  $2,505.00
Western blot of recombinant DIO3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant DIO3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

DIO3 Antibody (aa11-277, FITC) LS-C695671
Rabbit Polyclonal (IgG) to Rat DIO3
Rat
IHC WB
FITC Conjugated
20µl  $215.00; 100µl  $285.00; 200µl  $345.00; 1ml  $680.00; 10ml  $2,730.00
Western blot of recombinant DIO3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant DIO3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

DIO3 Antibody (aa11-277, Cy3) LS-C704505
Rabbit Polyclonal (IgG) to Rat DIO3
Rat
IHC WB
Cy3 Conjugated
20µl  $255.00; 100µl  $375.00; 200µl  $465.00; 1ml  $1,140.00; 10ml  $4,560.00
Western blot of recombinant DIO3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant DIO3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

DIO3 Antibody (aa11-277, PE) LS-C727592
Rabbit Polyclonal (IgG) to Rat DIO3
Rat
IHC WB
PE Conjugated
20µl  $215.00; 100µl  $285.00; 200µl  $345.00; 1ml  $680.00; 10ml  $2,730.00
Western blot of recombinant DIO3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant DIO3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

DIO3 Antibody (aa11-277, APC, Cy7) LS-C736504
Rabbit Polyclonal (IgG) to Rat DIO3
Rat
IHC WB
APC, Cy7 Conjugated
20µl  $295.00; 100µl  $475.00; 200µl  $680.00; 1ml  $1,710.00; 10ml  $6,840.00
Western blot of recombinant DIO3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant DIO3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

DIO3 Antibody (aa11-277, APC) LS-C718830
Rabbit Polyclonal (IgG) to Rat DIO3
Rat
IHC WB
APC Conjugated
20µl  $225.00; 100µl  $315.00; 200µl  $385.00; 1ml  $860.00; 10ml  $4,785.00
Western blot of recombinant DIO3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant DIO3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

DIO3 Antibody (aa17-66) LS-C199830
Rabbit Polyclonal (IgG) to Human DIO3
Mouse, Rat, Human
Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Western blot analysis of lysate from HUVEC cells, using DIO3 antibody.
Western blot analysis of lysate from HUVEC cells, using DIO3 antibody.

DIO3 Antibody (aa37-278) LS-C371085
Rabbit Polyclonal (IgG) to Rat DIO3
Rat
ELISA WB
Unconjugated
50µg  $285.00; 100µg  $385.00

DIO3 Antibody (Internal) LS-C352116
Rabbit Polyclonal to Human DIO3
Mouse, Rat, Human
WB
Unconjugated
100µl 1mg/ml  $245.00
Western blot analysis of DIO3 expression in HepG2 (A) whole cell lysates.
Western blot analysis of DIO3 expression in HepG2 (A) whole cell lysates.
Showing 1-25 of 43 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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