DIO2

deiodinase, iodothyronine, type II

Type II iodothyronine deiodinase activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3&#039,5-triiodothyronine (T3). Thyroid hormone appears to have important regulatory effects in some mammalian tissues, such as the developing brain, the anterior pituitary gland, and brown adipose tissue. A relatively high proportion of the receptor-bound triiodothyronine is found within the tissue itself rather than in plasma. The expression in these tissues of type II iodothyronine deiodinase, suggests that deiodinase II is responsible for this &#039local&#039 production of T3 and is thus important in influencing thyroid hormone action in these tissues. In addition, DIO2 activity is markedly elevated in the hypothyroid state and appears to be responsible for catalyzing the production of a large proportion of the circulating T3 under such conditions. Dioiodinase 2 may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease, toxic adenomas, and, perhaps, iodine deficiency. Alternative splice variants are formed due to the presence or absence of an unspliced intron in the 5&#039 untranslated region.

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Products

ELISA Kits (10)

Type

Competitive EIA (1)

Custom (6)

Sandwich (3)

Target

DIO2 (10)

Reactivity

Human (3)

Mouse (2)

Rat (2)

Chicken (1)

Pig (1)

Format

96-Well Strip Plate (10)

Publications

No (10)

Sample Type

Cell Lysates (1)

Plasma (1)

Serum (1)

Tissue Homogenates (4)

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Rat DIO2 (Sandwich ELISA) ELISA Kit - LS-F8107

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$783

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Human DIO2 (Sandwich ELISA) ELISA Kit - LS-F9623

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$730

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Rat DIO2 (Custom ELISA) ELISA Kit - LS-F14823

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Chicken DIO2 (Custom ELISA) ELISA Kit - LS-F14824

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Mouse DIO2 (Custom ELISA) ELISA Kit - LS-F14825

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Bovine DIO2 (Custom ELISA) ELISA Kit - LS-F14826

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Human DIO2 (Custom ELISA) ELISA Kit - LS-F14827

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Pig DIO2 (Custom ELISA) ELISA Kit - LS-F14828

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Pig

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Mouse DIO2 (Sandwich ELISA) ELISA Kit - LS-F8459

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$748

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Human DIO2 (Competitive EIA) ELISA Kit - LS-F39369

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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