Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Type II iodothyronine deiodinase activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). Thyroid hormone appears to have important regulatory effects in some mammalian tissues, such as the developing brain, the anterior pituitary gland, and brown adipose tissue. A relatively high proportion of the receptor-bound triiodothyronine is found within the tissue itself rather than in plasma. The expression in these tissues of type II iodothyronine deiodinase, suggests that deiodinase II is responsible for this 'local' production of T3 and is thus important in influencing thyroid hormone action in these tissues. In addition, DIO2 activity is markedly elevated in the hypothyroid state and appears to be responsible for catalyzing the production of a large proportion of the circulating T3 under such conditions. Dioiodinase 2 may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease, toxic adenomas, and, perhaps, iodine deficiency. Alternative splice variants are formed due to the presence or absence of an unspliced intron in the 5' untranslated region.
deiodinase, iodothyronine, type II
DIO2, 5DII, D2, DIOII, ITDI2, Type 2 DI, TXDI2, Type-II 5-deiodinase, SelY, Type-II 5deiodinase, Thyroxine deiodinase, type II