DICER1 / Dicer

dicer 1, ribonuclease type III

Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.

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Products

Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

DICER1 / Dicer (8)

Publications

No (8)

Tag

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (6)

Species

Human (6)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (4)

Wheat Germ Extract (1)

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DICER1 / Dicer Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G109485

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

218.5 kDa

Price:

100 µg/$710

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DICER1 / Dicer Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104907

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

218.5 kDa

Price:

100 µg/$710

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Human DICER1 / Dicer Protein (Recombinant His-T7) (aa6-290) - LS-G26078

Source:

E. coli

Tag:

His-T7

Molecular Weight:

35.8 kDa

Price:

10 µg/$273; 50 µg/$392; 100 µg/$627; 200 µg/$785; 1 mg/$1,852; 500 µg/$1,409; 5 mg/$2,814; 2 mg/$2,035

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Human DICER1 / Dicer Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70013

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

218.5 kDa

Price:

20 µg/$1,107

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Human DICER1 / Dicer Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70014

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

218.5 kDa

Price:

20 µg/$1,107

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Human DICER1 / Dicer Protein (Recombinant GST, N-terminus) (aa1813-1912) - LS-G61983

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human DICER1 / Dicer Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86085

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

218.5 kDa

Price:

20 µg/$215

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Human DICER1 / Dicer Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86084

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

218.5 kDa

Price:

20 µg/$215

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