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DHRS9

dehydrogenase/reductase (SDR family) member 9

DHRS9 is a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants.

Gene Name: dehydrogenase/reductase (SDR family) member 9
Synonyms: DHRS9, 3-alpha-HSD, 3ALPHA-HSD, RDH-E2, RDHL, RDH15, Retinol dehydrogenase homolog, RDH-TBE, RETSDR8, SDR9C4
Target Sequences: AF240697 NP_005762.2 Q9BPW9

Publications (2)

1
Downregulation of DHRS9 expression in colorectal cancer tissues and its prognostic significance. Hu L, Chen HY, Han T, Yang GZ, Feng D, Qi CY, Gong H, Zhai YX, Cai QP, Gao CF. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2016 37:837-45. (IHC; Human) [Full Text Article] [PubMed:26254099] [PMC:PMC4841860] Related Antibodies: LS-C145077.
2
Prognostic Impact of DHRS9 Overexpression in Pancreatic Cancer. Huang-Bao Li, Jun Zhou, Fengqing Zhao, Jiayin Yu, Longsheng Xu. Cancer management and research. 2020 August;12:5997-6006. [Full Text Article] [PubMed:32765099] [PMC:PMC7381829] Related Antibodies: LS-C145077.

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Proteins (15)
Over-Expression Lysate (10)
Recombinant (5)
DHRS9 (15)
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GST (1)
His (1)
Myc-DDK (Flag) (13)
Human (10)
293T Cells (5)
E. coli (1)
HEK 293 Cells (8)
Wheat Germ Extract (1)
Purified (2)
DHRS9 Protein - Purified recombinant protein DHRS9 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
35 kDa
20 µg/$1,107
DHRS9 Protein - Purified recombinant protein DHRS9 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
35 kDa
20 µg/$1,107
DHRS9 Protein - Purified recombinant protein DHRS9 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
35 kDa
20 µg/$1,107
DHRS9 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
35 kDa
100 µg/$494
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HEK 293 Cells
Myc-DDK (Flag)
35 kDa
100 µg/$494
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HEK 293 Cells
Myc-DDK (Flag)
35 kDa
100 µg/$494
DHRS9 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
35 kDa
100 µg/$494
DHRS9 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
35 kDa
100 µg/$494
DHRS9 Protein
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E. coli
His
50 µg/$411; 250 µg/$985; 10 µg/$276
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293T Cells
Myc-DDK (Flag)
35 kDa
20 µg/$150
DHRS9 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
35 kDa
20 µg/$150
DHRS9 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
35 kDa
20 µg/$150
DHRS9 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
35 kDa
20 µg/$150
Select
293T Cells
Myc-DDK (Flag)
35 kDa
20 µg/$150
DHRS9 Protein - 12.5% SDS-PAGE of human DHRS9 stained with Coomassie Blue
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Wheat Germ Extract
GST
60.83 kDa
10 µg/$479; 25 µg/$670
Viewing 1-15 of 15 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).