Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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dehydrogenase/reductase (SDR family) member 9
DHRS9 is a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants.
Downregulation of DHRS9 expression in colorectal cancer tissues and its prognostic significance. Hu L, Chen HY, Han T, Yang GZ, Feng D, Qi CY, Gong H, Zhai YX, Cai QP, Gao CF. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2016 37:837-45. (IHC; Human)[Full Text Article]
Related Antibodies: LS-C145077.