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DHRS2 / HEP27

dehydrogenase/reductase (SDR family) member 2

Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.

Gene Name: dehydrogenase/reductase (SDR family) member 2
Synonyms: DHRS2, Dicarbonyl reductase HEP27, HEP27, Protein D, SDR25C1
Target Sequences: NM_005794 NP_005785.1 Q13268

☰ Filters
Products
Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
DHRS2 / HEP27 (5)
No (5)
GST (1)
GST, N-terminus (2)
Myc-DDK (Flag) (2)
Human (4)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (2)
DHRS2 / HEP27 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
DHRS2 / HEP27 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
31.3 kDa
100 µg/$494
DHRS2 / HEP27 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
DHRS2 / HEP27 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
31.3 kDa
20 µg/$150
DHRS2 / HEP27 Protein - 12.5% SDS-PAGE of human DHRS2 stained with Coomassie Blue
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Wheat Germ Extract
GST
58.74 kDa
2 µg/$439
Viewing 1-5 of 5 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).