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DHCR24 / Seladin-1

24-dehydrocholesterol reductase

DHCR24 / Seladin-1 is a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.

Gene Name: 24-dehydrocholesterol reductase
Synonyms: DHCR24, DCE, Diminuto/dwarf1 homolog, KIAA0018, Nbla03646, Seladin 1, Seladin-1, SELADIN1, Selective AD indicator 1, Delta(24)-sterol reductase
Target Sequences: NM_014762 NP_055577.1 Q15392

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).