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Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate.
Gene Name: | derlin 3 |
Synonyms: | DERL3, C22orf14, Der1-like protein 3, Derlin 3, Derlin-3, DERtrin-3, IZP6, LLN2, DER3, DERtrin 3 |
Target Sequences: | Q96Q80 Q96Q80 |
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