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DEPDC2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.
| Gene Name: | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 |
| Synonyms: | PREX2, DEP domain containing 2, DEP.2, DEPDC2, P-REX2 |
| Target Sequences: | NM_025170 NP_079446.3 Q70Z35 |
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