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May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.
Gene Name: | DEP domain containing 1 |
Synonyms: | DEPDC1, DEP domain containing 1, DEPDC1A, DEP.8, SDP35, DEPDC1-V2 |
Target Sequences: | NM_017779 NP_060249.2 Q5TB30 |
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