LSBio
LSBio
Products
Services
Research Areas
Resources
Contact Us
Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121

Phone: 866-819-4732 (Toll Free North America)
206-374-1102 (International)

Fax: 866-206-6909 (Toll Free North America)
206-577-4565 (International)

How to Buy - Details about how to buy our products.

Orders@LSBio.com - To submit a new order.

Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, proforma invoice requests, or other billing issues.

Technical.Support@LSBio.com - To request technical information requests about an LSBio product or its application.

Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.

Worldwide Distributors List - To find your local distributor if you're not within the United States.
Products
Services
Research Areas
Resources
Contact Us

DENN / MADD

MAP-kinase activating death domain

MAP kinase-activating death domain protein (MADD) was initially identified as the type 1 tumor necrosis factor receptor (TNFR1) associated protein though their death domains. Overexpression of MADD activates MAP kinases ERK and JNK and induces the phosphorylation of cytosolic phospholipase A2 (1). MADD shares 98% identity with DENN (for differentially expressed in neoplastic vs. normal cells), which was recently identified as a substrate for c-jun N-terminal kinase 3 (JNK3). MADD has greater than 94% overall identity to a GDP/GTP exchange protein Rab3-GEP. MADD is 87% identical to KIAA0358, a brain protein of unknown function. Identification of MADD as a component of the TNFR1 signaling complex and the similarity between MADD and Rab3-GEP provides a connection between TNFR1 activation and downstream MAP kinase activity through a guanine-nucleotide exchange protein.

Gene Name: MAP-kinase activating death domain
Synonyms: MADD, DENN, IG20, KIAA0358, Rab3 GDP/GTP exchange factor, RAB3GEP
Target Sequences: NM_003682 NP_003673.3 Q8WXG6

Filtered By: None
Target
DENN / MADD (13)
Reactivity
Human (13)
Mouse (11)
Rat (7)
Bovine (2)
Dog (3)
Guinea pig (2)
Horse (2)
Monkey (1)
Rabbit (1)
Application
IHC (6)
IHC-P (4)
WB (11)
ELISA (1)
ICC (1)
IF (5)
IP (3)
Peptide-ELISA (2)
Host
rabbit (13)
Isotype
IgG (12)
Clonality
polyclonal pc (13)
Format
AP Conjugated (1)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
PE Conjugated (1)
Unconjugated (8)
Epitope
aa1597-1647 (2)
720-800 aa, Internal (1)
C-Terminus (1)
Internal (1)
aa1100-1150 (1)
aa729-778 (1)
aa751-800 (1)
Publications
No (13)
Showing 1-13 of 13 results

DENN / MADD Antibody (C-Terminus) IHC-plus™ LS-B583
Rabbit Polyclonal (IgG) to Human DENN / MADD
Mouse, Rat, Human
ICC IF IHC IHC-P WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-MADD antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Immunofluorescence of MADD in HeLa cells with MADD antibody at 20 ug/ml.
Anti-MADD antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Immunofluorescence of MADD in HeLa cells with MADD antibody at 20 ug/ml.

DENN / MADD Antibody (aa1597-1647) IHC-plus™ LS-B14430
Rabbit Polyclonal (IgG) to Human DENN / MADD
Mouse, Dog, Guinea pig, Bovine, Rat, Horse, Human
IF IHC IHC-P IP
Unconjugated
50µl 1mg/ml  $425.00
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

DENN / MADD Antibody (aa751-800) LS-C119176
Rabbit Polyclonal (IgG) to Human DENN / MADD
Mouse, Rat, Human
IF IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using MADD Antibody. The picture on the right is blocked with the synthesized peptide.
Immunofluorescence analysis of A549 cells, using MADD Antibody. The picture on the right is blocked with the synthesized peptide.
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using MADD Antibody. The picture on the right is blocked with the synthesized peptide.
Immunofluorescence analysis of A549 cells, using MADD Antibody. The picture on the right is blocked with the synthesized peptide.

DENN / MADD Antibody (720-800 aa, Internal) LS-C384399
Rabbit Polyclonal (IgG) to Human DENN / MADD
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of MADD antibody
Western blot of MADD antibody
Western blot of MADD antibody
Western blot of MADD antibody

DENN / MADD Antibody (aa1597-1647) LS-C285973
Rabbit Polyclonal (IgG) to Human DENN / MADD
Mouse, Dog, Guinea pig, Bovine, Rat, Horse, Human
IF IHC IHC-P
Unconjugated
100µl  $415.00
Detection of Human MADD by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-MADD used at a dilution of 1:100.
Detection of Human MADD by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-MADD used at a dilution of 1:100. Detection: Red-fluorescent Goat anti-Rabbit IgG-heavy and light chain cross-adsorbed Antibody DyLight 594 Conjugated (A120-601D4) used at a dilution of 1:100.
Detection of Human MADD by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-MADD used at a dilution of 1:100.
Detection of Human MADD by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-MADD used at a dilution of 1:100. Detection: Red-fluorescent Goat anti-Rabbit IgG-heavy and light chain cross-adsorbed Antibody DyLight 594 Conjugated (A120-601D4) used at a dilution of 1:100.

DENN / MADD Antibody (aa729-778) LS-C292152
Rabbit Polyclonal (IgG) to Human DENN / MADD
Mouse, Rat, Human
IHC Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Western blot analysis of the lysates from HepG2 cells using MADD antibody.
Western blot analysis of the lysates from HepG2 cells using MADD antibody.

DENN / MADD Antibody (aa1100-1150) LS-C288896
Rabbit Polyclonal (IgG) to Human DENN / MADD
Rabbit, Dog, Rat, Human
IP WB
Unconjugated
100µl 0.2mg/ml  $395.00

DENN / MADD Antibody (Internal) LS-C353071
Rabbit Polyclonal to Human DENN / MADD
Human, Monkey
IP WB
Unconjugated
100µl 1mg/ml  $245.00
Western blot analysis of MADD expression in HeLa (A); A431 (B); K562 (C) whole cell lysates.
Western blot analysis of MADD expression in HeLa (A); A431 (B); K562 (C) whole cell lysates.

DENN / MADD Antibody (HRP) LS-C547755
Rabbit Polyclonal (IgG) to Human DENN / MADD
Mouse, Human
WB
HRP Conjugated
100µl  $680.00

DENN / MADD Antibody (Biotin) LS-C527656
Rabbit Polyclonal (IgG) to Human DENN / MADD
Mouse, Human
WB
Biotin Conjugated
100µl  $680.00

DENN / MADD Antibody (FITC) LS-C537621
Rabbit Polyclonal (IgG) to Human DENN / MADD
Mouse, Human
WB
FITC Conjugated
100µl  $680.00

DENN / MADD Antibody (AP) LS-C509629
Rabbit Polyclonal (IgG) to Human DENN / MADD
Mouse, Human
WB
AP Conjugated
100µl  $680.00

DENN / MADD Antibody (PE) LS-C655794
Rabbit Polyclonal (IgG) to Human DENN / MADD
Mouse, Human
WB
PE Conjugated
100µl  $680.00
Showing 1-13 of 13 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

Get Social With Us!
Follow us on Facebook Follow us on Google+ Follow us on LinkedIn PSL Alliance Member
Copyright © 2018 LifeSpan BioSciences, Inc. All Rights Reserved Privacy Policy