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DEGS1 is a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor.
Gene Name: | delta(4)-desaturase, sphingolipid 1 |
Synonyms: | DEGS1, Des-1, DES1, FADS7, MLD, MIG15, DEGS, DEGS-1, Dihydroceramide desaturase, Membrane lipid desaturase |
Target Sequences: | NM_003676 NP_003667.1 O15121 |
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