DDX39B / UAP56

DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B

Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability.Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [PubMed:23299939] reporting a stimulatory effect.

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Proteins (10)

Type

Over-Expression Lysate (4)

Recombinant (6)

Target

DDX39B / UAP56 (10)

Publications

No (10)

Tag

GST (1)

GST, N-terminus (2)

His (1)

Myc-DDK (Flag) (6)

Species

Human (8)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human DDX39B / UAP56 Protein (Recombinant GST, N-terminus) (Full Length) - LS-G22050

Source:

E. coli

Tag:

GST, N-terminus

Molecular Weight:

55.6 kD

Price:

100 µg/$420; 20 µg/$323; 1 mg/$1,355

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DDX39B / UAP56 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107850

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.8 kDa

Price:

100 µg/$494

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Human DDX39B / UAP56 Protein (Recombinant GST) (Full Length) - LS-G31032

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

72.82 kDa

Price:

2 µg/$439

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Human DDX39B / UAP56 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66644

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.8 kDa

Price:

20 µg/$1,107

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Human DDX39B / UAP56 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66645

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.8 kDa

Price:

20 µg/$1,107

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Human DDX39B / UAP56 Protein (Recombinant GST, N-terminus) (aa329-428) - LS-G64660

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human DDX39B / UAP56 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78175

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.8 kDa

Price:

20 µg/$150

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Human DDX39B / UAP56 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78176

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.8 kDa

Price:

20 µg/$150

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DDX39B / UAP56 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100354

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.8 kDa

Price:

100 µg/$494

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Human DDX39B / UAP56 Protein (Recombinant His) - LS-G939

Source:

E. coli

Tag:

His

Price:

50 µg/$361; 250 µg/$739; 10 µg/$261; 20 µg/$298; 100 µg/$454; 500 µg/$1,177

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