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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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DDX / AKR1C3
aldo-keto reductase family 1, member C3
DDX / AKR1C3 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | aldo-keto reductase family 1, member C3 |
| Synonyms: | AKR1C3, 3-alpha-HSD type 2, 17-beta-HSD 5, 3-alpha-HSD type II, brain, DD3, DDH1, DDX, Dihydrodiol dehydrogenase 3, Dihydrodiol dehydrogenase X, DD-3, HA1753, HAKRe, HAKRB, HSD17B5, KIAA0119, Kia0119, Prostaglandin F synthase, PGFS, Truncated aldoketo reductase a, HluPGFS, Indanol dehydrogenase |
| Target Sequences: | AF110411 IPI00031381.1 P42330 |
Publications (2)
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