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DDIT3 / CHOP

DNA-damage-inducible transcript 3

Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.

Gene Name: DNA-damage-inducible transcript 3
Synonyms: DDIT3, CHOP10, DDIT-3, CHOP, GADD153, C/EBP zeta, C/EBP-homologous protein, C/EBP-homologous protein 10, CHOP-10
Target Sequences: NM_004083 NP_004074.2 P35638

☰ Filters
Antibodies (96)
Proteins (11)
ELISA Kits (9)
Cell-Based (1)
Competitive EIA (1)
Custom (1)
Over-Expression Lysate (4)
Primary (96)
Recombinant (7)
Sandwich (6)
DDIT3 / CHOP (116)
Human (92)
Mouse (60)
Rat (31)
Bat (4)
Bovine (5)
Chimpanzee (3)
Dog (4)
Guinea pig (4)
Horse (4)
Monkey (2)
Orangutan (3)
Pig (3)
Sheep (5)
IHC (40)
IHC-P (20)
WB (85)
Flo (17)
ELISA (30)
ICC (11)
IF (26)
IP (8)
Peptide-ELISA (3)
rabbit (73)
mouse (23)
Product Group
IHCPlus (5)
IgG (44)
IgG1 (8)
IgG1,k (1)
IgG2a (5)
IgG2b (1)
IgG2b,k (4)
monoclonal mc (24)
polyclonal pc (72)
11C1019 (1)
1E1 (1)
2G3 (1)
3H7 (2)
4C3 (1)
9C8 (5)
OTI1E7 (2)
OTI2D3 (2)
OTI4C4 (2)
OTI4G2 (2)
96-Well Microplate (1)
96-Well Strip Plate (8)
AP Conjugated (2)
APC (2)
APC Conjugated (4)
Azide-free (2)
Biotin Conjugated (7)
Carrier-free (5)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
DY488 Conjugated (1)
DY550 Conjugated (1)
DY650 Conjugated (1)
FITC Conjugated (6)
HRP Conjugated (6)
PE Conjugated (4)
Preservative Free (3)
Unconjugated (60)
aa1-168 (8)
aa1-169 (8)
aa120-149 (8)
aa82-110 (8)
pSer30 (5)
aa28-77 (4)
10-90 aa (2)
60-140 aa, Internal (1)
Gln26 (1)
Internal (1)
Lys121 (1)
N-Terminus (1)
aa124 (1)
aa15-64 (1)
aa91-140 (1)
p30 (1)
No (116)
Adherent Cell Cultures (1)
Cell Culture Supernatants (1)
Cell Lysates (2)
Plasma (5)
Serum (5)
Tissue Homogenates (5)
GST (1)
GST, N-terminus (2)
GST, N-terminus + His, C-terminus (1)
His (2)
His-GST (1)
Myc-DDK (Flag) (4)
Human (8)
Mouse (1)
293T Cells (2)
E. coli (4)
HEK 293 Cells (2)
Wheat Germ Extract (3)
Purified (2)
DDIT3 / CHOP Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
DDIT3 / CHOP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$440
DDIT3 / CHOP Antibody - Anti-DDIT3 / CHOP antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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DDIT3 / CHOP Mouse anti-Human Monoclonal (3H7) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$440
Select
DDIT3 / CHOP Rabbit anti-Human Monoclonal (11C1019) Antibody
Mouse, Rat, Human
IP, WB
Unconjugated
100 µl/$580
DDIT3 / CHOP Antibody - Immunohistochemical analysis of GADD153 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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DDIT3 / CHOP Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Pig, Human, Monkey
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$289
DDIT3 / CHOP Antibody - Fluorescent image of HeLa cell stained with DDIT3 Antibody (C-term A135). HeLa cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with DDIT3 primary antibody (1:25, 1 h at 37°C). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37°C). Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37°C). DDIT3 immunoreactivity is localized to Cytoplasm significantly.
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DDIT3 / CHOP Rabbit anti-Human Polyclonal (aa120-149) Antibody
Mouse, Human
Flo, IF, WB
Unconjugated
400 µl/$376
DDIT3 / CHOP Antibody - Immunohistochemical analysis of GADD153 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
DDIT3 / CHOP Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Sheep, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$289
DDIT3 / CHOP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$746
DDIT3 / CHOP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$821
DDIT3 / CHOP ELISA Kit
Select
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$571
DDIT3 / CHOP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
DDIT3 / CHOP Antibody - Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue, using CHOP Antibody. The picture on the right is blocked with the synthesized peptide.
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DDIT3 / CHOP Rabbit anti-Human Polyclonal (aa15-64) Antibody
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$318; 100 µl/$378
DDIT3 / CHOP Antibody - Western blot of Human Stomach Tumor. DDIT3 antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DDIT3 / CHOP Rabbit anti-Human Polyclonal (aa28-77) Antibody
Mouse, Dog, Guinea pig, Sheep, Bovine, Rat, Horse, Bat, Human
WB
Unconjugated
100 µl/$414
DDIT3 / CHOP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$744
DDIT3 / CHOP ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$746
Select
DDIT3 / CHOP Rabbit anti-Human Polyclonal (aa82-110) (FITC) Antibody
Human
ELISA, Flo, WB
FITC Conjugated
200 µl/$828
Select
DDIT3 / CHOP Rabbit anti-Human Polyclonal (aa82-110) (APC) Antibody
Human
ELISA, Flo, WB
APC Conjugated
200 µl/$828
DDIT3 / CHOP Antibody - DDIT3 Antibody western blot of Jurkat cell line lysates (35 ug/lane). The DDIT3 antibody detected the DDIT3 protein (arrow).
Select
DDIT3 / CHOP Rabbit anti-Human Polyclonal (aa82-110) Antibody
Human
Flo, WB
Unconjugated
400 µl/$381
DDIT3 / CHOP Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using GADD153 Antibody. The picture on the right is blocked with the synthesized peptide.
Select
DDIT3 / CHOP Rabbit anti-Human Polyclonal (aa91-140) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$318; 100 µl/$378
DDIT3 / CHOP Protein
Select
E. coli
His
100 µg/$401; 500 µg/$925; 20 µg/$264
DDIT3 / CHOP Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-DDIT3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
Select
DDIT3 / CHOP Mouse anti-Human Monoclonal (OTI2D3) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$409
DDIT3 / CHOP Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
DDIT3 / CHOP Rabbit anti-Human Polyclonal (10-90 aa) Antibody
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
Select
DDIT3 / CHOP Rabbit anti-Human Polyclonal (aa124) Antibody
Mouse, Rat, Human
IHC, IP, WB
Unconjugated
100 µg/$546
Select
DDIT3 / CHOP Rabbit anti-Human Polyclonal (aa120-149) (Biotin) Antibody
Mouse, Human
ELISA, Flo, WB
Biotin Conjugated
200 µl/$825
Select
DDIT3 / CHOP Rabbit anti-Human Polyclonal (aa120-149) (FITC) Antibody
Mouse, Human
ELISA, Flo, WB
FITC Conjugated
200 µl/$825
Select
DDIT3 / CHOP Rabbit anti-Human Polyclonal (aa120-149) (APC) Antibody
Mouse, Human
ELISA, Flo, WB
APC Conjugated
200 µl/$825
Viewing 1-25 of 116 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).