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Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P), phosphatidylinositol 5-phosphate (PI5P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane.
Gene Name: | DDHD domain containing 2 |
Synonyms: | DDHD2, DDHD domain containing 2, KIAA0725, Phospholipase DDHD2, SAMWD1, SPG54, PA-PLA1 like |
Target Sequences: | AK023218 NP_056029.2 O94830 |
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