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Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety.
Gene Name: | decapping mRNA 2 |
Synonyms: | DCP2, MRNA-decapping enzyme 2, Nudix motif 20, NUDT20, HDpc, M7GpppN-mRNA hydrolase |
Target Sequences: | N57265 Q8IU60 Q8IU60 |
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