DCLK2 / DCAMKL2

doublecortin-like kinase 2

DCLK2 / DCAMKL2 is a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified.

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ELISA Kits (1)

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Cell-Based (1)

Target

DCLK2 / DCAMKL2 (1)

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Human (1)

Mouse (1)

Format

96-Well Microplate (1)

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Adherent Cell Cultures (1)

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Mouse/Human DCLK2 / DCAMKL2 (Cell-Based ELISA) ELISA Kit - LS-F3253

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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