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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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DCLK / DCLK1

doublecortin-like kinase 1

DCLK / DCLK1 is a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.

Gene Name: doublecortin-like kinase 1
Family/Subfamily: Protein Kinase , DCAMKL
Synonyms: DCLK1, CLICK1, DCAMKL1, Doublecortin-like kinase 1, KIAA0369, CAMKLK, CL1, DCDC3A, DCLK
Target Sequences: NM_004734 NP_004725.1 O15075

Publications (1)

1
Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. Gerbe F, van Es JH, Makrini L, Brulin B, Mellitzer G, Robine S, Romagnolo B, Shroyer NF, Bourgaux JF, Pignodel C, Clevers H, Jay P. The Journal of cell biology. 2011 192:767-80. [PubMed:21383077] [PMC:PMC3051826] Related Antibodies: LS-C100746.

Filtered By: None
Target
DCLK / DCLK1 (54)
Reactivity
Human (46)
Mouse (39)
Rat (3)
Bovine (5)
Chicken (4)
Chimpanzee (3)
Dog (1)
Gibbon (3)
Guinea pig (4)
Horse (5)
Monkey (4)
Orangutan (3)
Pig (12)
Rabbit (5)
Xenopus (4)
Application
IHC (22)
IHC-P (4)
WB (47)
ELISA (30)
ICC (8)
IF (11)
IP (1)
Host
rabbit (51)
mouse (3)
Isotype
IgG (40)
IgG1,k (1)
IgG2b,k (1)
Clonality
monoclonal mc (3)
polyclonal pc (51)
Clone
1751CT665.1.72 (1)
Format
AP Conjugated (3)
APC (1)
APC Conjugated (4)
Azide-free (3)
Biotin Conjugated (7)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (7)
HRP Conjugated (6)
PE Conjugated (4)
Unconjugated (21)
Epitope
aa390-647 (10)
aa1-30 (8)
aa153-181 (8)
aa690-720 (8)
aa254-303 (4)
N-Terminus (1)
aa640-729 (1)
aa685-712 (1)
aa690-740 (1)
Publications
No (53)
Yes (1)
Showing 1-25 of 54 results

DCLK / DCLK1 Antibody IHC-plus™ LS-B15568
Rabbit Polyclonal (IgG) to Human DCLK / DCLK1
Mouse, Rat, Human
IF IHC IHC-P WB
Unconjugated
50µl  $425.00
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)

DCLK / DCLK1 Antibody (aa690-720) LS-C100746
Publications (1)
Publications (1)
Rabbit Polyclonal to Human DCLK / DCLK1
Mouse, Human
IF IHC IHC-P WB
Unconjugated
400µl  $305.00
Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with DCAMKL1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Expression pattern of doublecortin and CaM kinase-like-1 (DCAMKL-1) in normal mouse small intestine. (A): Immunohistochemical staining of normal small intestine for DCAMKL-1. Arrows indicate the cells positive for DCAMKL-1 in the stem cell zone. (B): Preincubation with blocking peptide completely abolished DCAMKL-1 immunoreactivity. (C): Immunohistochemical staining of normal small intestine for DCAMKL-1. Brown indicates the cells positive for DCAMKL-1 (indicated by the arrows).
Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with DCAMKL1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Expression pattern of doublecortin and CaM kinase-like-1 (DCAMKL-1) in normal mouse small intestine. (A): Immunohistochemical staining of normal small intestine for DCAMKL-1. Arrows indicate the cells positive for DCAMKL-1 in the stem cell zone. (B): Preincubation with blocking peptide completely abolished DCAMKL-1 immunoreactivity. (C): Immunohistochemical staining of normal small intestine for DCAMKL-1. Brown indicates the cells positive for DCAMKL-1 (indicated by the arrows).

DCLK / DCLK1 Antibody (N-Terminus) LS-C108672
Rabbit Polyclonal (IgG) to Human DCLK / DCLK1
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
100µg 1mg/ml  $365.00
Immunohistochemistry of DCLK1 in mouse brain tissue with DCLK1 Antibodyat 5 µg/mL.
Immunohistochemistry of DLCK1 in rat brain tissue with DLCK1 antibody at 2.5 µg/mL.
Immunohistochemistry of DCLK1 in mouse brain tissue with DCLK1 Antibodyat 5 µg/mL.
Immunohistochemistry of DLCK1 in rat brain tissue with DLCK1 antibody at 2.5 µg/mL.

DCLK / DCLK1 Antibody (aa690-720) LS-C320752
Rabbit Polyclonal (IgG) to Human DCLK / DCLK1
Mouse, Human
ELISA IF IHC WB
Unconjugated
200µl  $530.00

DCLK / DCLK1 Antibody (aa690-720, Biotin) LS-C255887
Rabbit Polyclonal (IgG) to Human DCLK / DCLK1
Mouse, Human
ELISA ICC IF IHC WB
Biotin Conjugated
200µl  $680.00

DCLK / DCLK1 Antibody (aa690-720, FITC) LS-C255888
Rabbit Polyclonal (IgG) to Human DCLK / DCLK1
Mouse, Human
ELISA ICC IF IHC WB
FITC Conjugated
200µl  $680.00

DCLK / DCLK1 Antibody (aa690-720, APC) LS-C255886
Rabbit Polyclonal (IgG) to Human DCLK / DCLK1
Mouse, Human
ELISA ICC IF IHC WB
APC Conjugated
200µl 0.5mg/ml  $635.00

DCLK / DCLK1 Antibody (aa690-720, AP) LS-C255885
Rabbit Polyclonal (IgG) to Human DCLK / DCLK1
Mouse, Human
ELISA ICC IF IHC WB
AP Conjugated
200µl  $680.00

DCLK / DCLK1 Antibody (aa690-720, Azide-free, HRP) LS-C255889
Rabbit Polyclonal (IgG) to Human DCLK / DCLK1
Mouse, Human
ELISA ICC IF IHC WB
HRP Conjugated, Azide-free
200µl  $680.00

DCLK / DCLK1 Antibody (aa690-720, PE) LS-C255890
Rabbit Polyclonal (IgG) to Human DCLK / DCLK1
Mouse, Human
ELISA ICC IF IHC WB
PE Conjugated
200µl  $680.00

DCLK / DCLK1 Antibody (aa690-740) IHC-plus™ LS-B13547
Rabbit Polyclonal to Human DCLK / DCLK1
Rabbit, Mouse, Dog, Bovine, Horse, Human
IHC IHC-P IP WB
Unconjugated
50µl 1mg/ml  $425.00
Human Colon, Submucosal Plexus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Colon, Submucosal Plexus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)

DCLK / DCLK1 Antibody (aa254-303) LS-C187332
Rabbit Polyclonal to Human DCLK / DCLK1
Xenopus, Chicken, Bovine, Rabbit, Guinea pig, Pig, Horse, Human, Monkey
WB
Unconjugated
50µg  $365.00
Western blot of Human 721_B. DCLK1 antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of Human 721_B. DCLK1 antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

DCLK / DCLK1 Antibody (aa640-729) LS-C307183
Mouse Monoclonal (IgG2b,k) to Human DCLK / DCLK1
Mouse, Human
ELISA IF WB
Unconjugated
50µg  $560.00

DCLK / DCLK1 Antibody LS-C751954
Rabbit Polyclonal (IgG) to Human DCLK / DCLK1
Human
ELISA IHC WB
Unconjugated
100µg  $335.00

DCLK / DCLK1 Antibody LS-C671432
Rabbit Polyclonal (IgG) to Human DCLK / DCLK1
Human
ELISA IHC IHC-P
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry image of paraffin-embedded human breast cancer at a dilution of 1:100
Immunohistochemistry image of paraffin-embedded human glioma cancer at a dilution of 1:100
Immunohistochemistry image of paraffin-embedded human breast cancer at a dilution of 1:100
Immunohistochemistry image of paraffin-embedded human glioma cancer at a dilution of 1:100

DCLK / DCLK1 Antibody (aa153-181) LS-C329458
Rabbit Polyclonal (IgG) to Mouse DCLK / DCLK1
Mouse
ELISA WB
Unconjugated
200µl  $530.00

DCLK / DCLK1 Antibody (aa153-181, Biotin) LS-C255916
Rabbit Polyclonal (IgG) to Mouse DCLK / DCLK1
Mouse
ELISA WB
Biotin Conjugated
200µl  $680.00

DCLK / DCLK1 Antibody (aa153-181, APC) LS-C255917
Rabbit Polyclonal (IgG) to Mouse DCLK / DCLK1
Mouse
ELISA WB
APC Conjugated
200µl  $680.00

DCLK / DCLK1 Antibody (aa153-181, Azide-free, HRP) LS-C255919
Rabbit Polyclonal (IgG) to Mouse DCLK / DCLK1
Mouse
ELISA WB
HRP Conjugated, Azide-free
200µl  $680.00

DCLK / DCLK1 Antibody (aa153-181, AP) LS-C255915
Rabbit Polyclonal (IgG) to Mouse DCLK / DCLK1
Mouse
ELISA WB
AP Conjugated
200µl  $680.00

DCLK / DCLK1 Antibody (aa390-647) LS-C373362
Rabbit Polyclonal (IgG) to Human DCLK / DCLK1
Mouse, Pig, Human
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $305.00; 1ml 0.5mg/ml  $530.00; 10ml 0.5mg/ml  $2,100.00
Western blot of DCLK / DCLK1 antibody.
Western blot of DCLK / DCLK1 antibody.

DCLK / DCLK1 Antibody LS-C405889
Rabbit Polyclonal (IgG) to Human DCLK / DCLK1
Mouse, Human
ELISA IHC
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human thyroid cancer using DCLK1 Polyclonal Antibody at dilution of 1:25.
Immunohistochemistry of Human thyroid cancer using DCLK1 Polyclonal Antibody at dilution of 1:25.
Immunohistochemistry of Human thyroid cancer using DCLK1 Polyclonal Antibody at dilution of 1:25.
Immunohistochemistry of Human thyroid cancer using DCLK1 Polyclonal Antibody at dilution of 1:25.

DCLK / DCLK1 Antibody (clone 1751CT665.1.72) LS-C757941
Mouse Monoclonal [clone 1751CT665.1.72] (IgG1,k) to Human DCLK / DCLK1
Mouse, Human
ELISA WB
Unconjugated
50µl  $215.00; 200µl  $325.00
All lanes: Anti-DCLK1 Antibody at 1:4000 dilution Lane 1: human brain lysate Lane 2: mouse brain lysate Lane 3: TT whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size: 82 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
All lanes: Anti-DCLK1 Antibody at 1:4000 dilution Lane 1: human brain lysate Lane 2: mouse brain lysate Lane 3: TT whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size: 82 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

DCLK / DCLK1 Antibody (aa1-30) LS-C327166
Rabbit Polyclonal (IgG) to Human DCLK / DCLK1
Mouse, Human
ELISA WB
Unconjugated
200µl 0.25mg/ml  $530.00

DCLK / DCLK1 Antibody LS-C402638
Rabbit Polyclonal (IgG) to Human DCLK / DCLK1
Mouse, Human
ELISA WB
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Western blot analysis of Mouse brain tissue, using DCLK1 Polyclonal Antibody at dilution of 1:200.
Western blot analysis of Mouse brain tissue, using DCLK1 Polyclonal Antibody at dilution of 1:200.
Showing 1-25 of 54 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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