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DCAF7 / WDR68

DDB1 and CUL4 associated factor 7

Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Name:	DDB1 and CUL4 associated factor 7
Synonyms:	DCAF7, Human anthocyanin, AN11, WD-repeat protein, WD repeat domain 68, HAN11, SWAN-1, WDR68
Target Sequences:	NM_005828 NP_005819.3 P61962

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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