DAPK3 / ZIP Kinase

death-associated protein kinase 3

Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca2+ and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor.

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ELISA Kits (7)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Custom (4)

Sandwich (1)

Target

DAPK3 / ZIP Kinase (7)

Reactivity

Human (4)

Mouse (4)

Rat (3)

Format

96-Well Microplate (3)

96-Well Strip Plate (4)

Publications

No (7)

Sample Type

Adherent Cell Cultures (2)

Tissue Homogenates (1)

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Mouse DAPK3 / ZIP Kinase (Custom) ELISA Kit - LS-F66155

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Price:

1 Plate/$783

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Human DAPK3 / ZIP Kinase (Custom) ELISA Kit - LS-F66385

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Price:

1 Plate/$783

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Human DAPK3 / ZIP Kinase (Custom ELISA) ELISA Kit - LS-F50330

Type:

Custom

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$923

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Rat DAPK3 / ZIP Kinase (Custom) ELISA Kit - LS-F65664

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Price:

1 Plate/$783

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Mouse DAPK3 / ZIP Kinase (Sandwich ELISA) ELISA Kit - LS-F8129

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$854

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Mouse/Human/Rat DAPK3 / ZIP Kinase (Cell-Based ELISA) ELISA Kit - LS-F1935

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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Mouse/Human/Rat Phospho-DAPK3 / ZIP Kinase (Thr265) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1350

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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