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DAG1 / Dystroglycan

dystroglycan 1 (dystrophin-associated glycoprotein 1)

The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.Alpha-dystroglycan is an extracellular peripheral glycoprotein that acts as a receptor for both extracellular matrix proteins containing laminin-G domains, and for certain adenoviruses. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for M.leprae in peripheral nerve Schwann cells but only in the presence of the G-domain of LAMA2, and for lymphocytic choriomeningitis virus, Old World Lassa fever virus, and clade C New World arenaviruses.Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.

Gene Name: dystroglycan 1 (dystrophin-associated glycoprotein 1)
Synonyms: DAG1, 156DAG, A3a, AGRNR, DAG, Dystroglycan, MDDGC7
Target Sequences: NM_004393

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Products
Proteins (3)
Recombinant (3)
DAG1 / Dystroglycan (3)
SDS-PAGE (1)
No (3)
GST, N-terminus (1)
His,C-terminus (1)
His-T7 (1)
Human (2)
Mouse (1)
E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Low endotoxin level (1)
DAG1 / Dystroglycan Protein - Recombinant  Dystrophin Associated Glycoprotein 1 By SDS-PAGE
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E. coli
His-T7
44.1 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
DAG1 / Dystroglycan Protein
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HEK 293 Cells
His,C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human DAG1 consists 731 amino acids and predicts a molecular mass of 79.7 kDa.
50 µg/$348
DAG1 / Dystroglycan Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Viewing 1-3 of 3 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).