DAD1

defender against cell death 1

Defender of cell death 1 (DAD1) was initially discovered in BHK21 cells as a negative regulator of programmed cell death, a process important for normal organism development and tissue homeostasis. DAD1 was later shown to be a subunit of the mammalian oligosaccharyltransferase complex and is required for its function and structural integrity. Mice lacking DAD1 express abnormal N-linked glycoproteins and undergo increased apoptotic-associated embryonic death. Furthermore, overexpression of DAD1 mRNA is seen in some human hepatocellular carcinomas, indicating it may also play a role in carcinogenesis. It should be noted that DAD1 is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.

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Proteins (1)

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Recombinant (1)

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DAD1 (1)

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No (1)

Tag

GST (1)

Species

Human (1)

Source

Wheat Germ Extract (1)

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Purified (1)

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Human DAD1 Protein (Recombinant GST) (Full Length) - LS-G28149

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

38.17 kDa

Price:

10 µg/$479; 25 µg/$670

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