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Unfortunately, the antibody (ID:162829) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



DAB2

Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)

Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containg non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor.

Gene Name: Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
Synonyms: DAB2, Disabled homolog 2, DOC-2, DOC2
Target Sequences: NM_001343 NP_001334.2 P98082

Filtered By: None
Target
dab2 (25)
Reactivity
Human (17)
Mouse (14)
Rat (6)
Bat (4)
Bovine (4)
Chimpanzee (3)
Dog (4)
Gibbon (3)
Guinea pig (4)
Monkey (4)
Orangutan (3)
Pig (4)
Rabbit (4)
Application
IHC (2)
IHC-P (1)
WB (25)
Flo (1)
ELISA (17)
IF (1)
IP (1)
Host
rabbit (23)
mouse (2)
Isotype
IgG (17)
IgG2a,k (1)
Clonality
monoclonal mc (1)
polyclonal pc (24)
Clone
1C8 (1)
Format
AP Conjugated (2)
APC Conjugated (2)
Azide-free (2)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (2)
Unconjugated (10)
Epitope
aa624-650 (8)
C-Terminus (7)
N-Terminus (4)
aa275-325 (1)
aa743-770 (1)
Publications
No (25)
Showing 1-25 out of 25 results
Anti-DAB2 Antibody (aa743-770) IHC-plus™ LS-B12091

Rabbit Polyclonal to Human DAB2
Human
Flo IHC-P WB
Unconjugated
Anti-DAB2 Antibody LS-C401580

Rabbit Polyclonal (IgG) to Human DAB2
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
Anti-DAB2 Antibody LS-C404871

Rabbit Polyclonal (IgG) to Human DAB2
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
Anti-DAB2 Antibody (aa624-650) LS-C320733

Rabbit Polyclonal (IgG) to Mouse DAB2
Mouse
ELISA WB
Unconjugated
Anti-DAB2 Antibody (aa624-650, Biotin) LS-C221983

Rabbit Polyclonal (IgG) to Mouse DAB2
Mouse
ELISA WB
Biotin Conjugated
Anti-DAB2 Antibody (aa624-650, FITC) LS-C221984

Rabbit Polyclonal (IgG) to Mouse DAB2
Mouse
ELISA WB
FITC Conjugated
Anti-DAB2 Antibody (aa624-650, AP) LS-C221981

Rabbit Polyclonal (IgG) to Mouse DAB2
Mouse
ELISA WB
AP Conjugated
Anti-DAB2 Antibody (aa624-650, PE) LS-C221986

Rabbit Polyclonal (IgG) to Mouse DAB2
Mouse
ELISA WB
PE Conjugated
Anti-DAB2 Antibody (aa624-650, Azide-free, HRP) LS-C221985

Rabbit Polyclonal (IgG) to Mouse DAB2
Mouse
ELISA WB
HRP Conjugated, Azide-free
Anti-DAB2 Antibody (aa624-650, APC) LS-C221982

Rabbit Polyclonal (IgG) to Mouse DAB2
Mouse
ELISA WB
APC Conjugated
Anti-DAB2 Antibody (clone 1C8) LS-C197016

Mouse Monoclonal [clone 1C8] (IgG2a,k) to Human DAB2
Human
ELISA WB
Unconjugated
Anti-DAB2 Antibody (C-Terminus) LS-C327162

Rabbit Polyclonal (IgG) to Human DAB2
Human
ELISA WB
Unconjugated
Anti-DAB2 Antibody (C-Terminus, Biotin) LS-C225052

Rabbit Polyclonal (IgG) to Human DAB2
Human
ELISA WB
Biotin Conjugated
Anti-DAB2 Antibody (C-Terminus, FITC) LS-C225054

Rabbit Polyclonal (IgG) to Human DAB2
Human
ELISA WB
FITC Conjugated
Anti-DAB2 Antibody (C-Terminus, Azide-free, HRP) LS-C225056

Rabbit Polyclonal (IgG) to Human DAB2
Human
ELISA WB
HRP Conjugated, Azide-free
Anti-DAB2 Antibody (C-Terminus, PE) LS-C225055

Rabbit Polyclonal (IgG) to Human DAB2
Human
ELISA WB
PE Conjugated
Anti-DAB2 Antibody (C-Terminus, AP) LS-C225050

Rabbit Polyclonal (IgG) to Human DAB2
Human
ELISA WB
AP Conjugated
Anti-DAB2 Antibody (C-Terminus, APC) LS-C225051

Rabbit Polyclonal (IgG) to Human DAB2
Human
ELISA WB
APC Conjugated
Anti-DAB2 Antibody LS-C307169

Mouse Polyclonal (IgG) to Human DAB2
Human
IF WB
Unconjugated
Anti-DAB2 Antibody (aa275-325) LS-C286191

Rabbit Polyclonal to Human DAB2
Human
IP WB
Unconjugated
Anti-DAB2 Antibody (aa624-650) LS-C157905

Rabbit Polyclonal to Mouse DAB2
Mouse
WB
Unconjugated
Anti-DAB2 Antibody (N-Terminus) LS-C201408

Rabbit Polyclonal to Human DAB2
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Bat, Human, Monkey
WB
Unconjugated
Anti-DAB2 Antibody (N-Terminus, HRP) LS-C442980

Rabbit Polyclonal to Human DAB2
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
WB
HRP Conjugated
Anti-DAB2 Antibody (N-Terminus, Biotin) LS-C442978

Rabbit Polyclonal to Human DAB2
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
Anti-DAB2 Antibody (N-Terminus, FITC) LS-C442979

Rabbit Polyclonal to Human DAB2
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
WB
FITC Conjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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