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CYR61

cysteine-rich, angiogenic inducer, 61

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

Gene Name: cysteine-rich, angiogenic inducer, 61
Synonyms: CYR61, GIG1, IGFBP10, Protein CYR61, CCN family member 1, CCN1, IBP-10, IGF-binding protein 10, IGFBP-10, Protein GIG1
Target Sequences: NM_001554 NP_001545.2 O00622

Publications (2)

1
Premenstrual regulation of the pro-angiogenic factor CYR61 in human endometrium. Gashaw I, Stiller S, Bing C, Kimmig R, Winterhager E. Endocrinology. 2008 149:2261-9. (ICC, IHC) [PubMed:18202125]
2
Extracellular matrix protein CCN1 limits oncolytic efficacy in glioma. Haseley A, Boone S, Wojton J, Yu L, Yoo JY, Yu J, Kurozumi K, Glorioso JC, Caligiuri MA, Kaur B. Cancer research. 2012 72:1353-62. [PubMed:22282654] [PMC:PMC3366191]

☰ Filters
Products
ELISA Kits (18)
Custom (1)
Sandwich (16)
Sandwich CLIA (1)
CYR61 (18)
Human (9)
Mouse (3)
Rat (1)
Chicken (2)
Monkey (1)
Porcine (1)
Rabbit (1)
12 x 8-Well Microstrips (1)
96-Well Microplate (3)
96-Well Strip Plate (14)
No (18)
Breast Milk (1)
Cell Culture Supernatants (3)
Cell Lysates (1)
Plasma (13)
Saliva (2)
Serum (13)
Tissue Homogenates (5)
Urine (2)
CYR61 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
6.25 - 400 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$748
CYR61 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
CYR61 ELISA Kit
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Sandwich
96-Well Microplate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Breast Milk, Cell Culture Supernatants, Plasma, Saliva, Serum, Urine
1 Plate/$901
CYR61 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
CYR61 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CYR61 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
18.75 - 1200 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$870
CYR61 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
CYR61 ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
CYR61 ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
1.25 - 80 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
CYR61 ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
1.563 - 100 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
CYR61 ELISA Kit
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Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$783
CYR61 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
CYR61 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CYR61 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
15.625 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
CYR61 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Urine
1 Plate/$624
CYR61 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$730
CYR61 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Saliva, Serum, Tissue Homogenates
1 Plate/$822
CYR61 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.137 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$635
Viewing 1-18 of 18 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).