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CYP2E1

cytochrome P450, family 2, subfamily E, polypeptide 1

CYP2E1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.

Gene Name: cytochrome P450, family 2, subfamily E, polypeptide 1
Family/Subfamily: Cytochrome P450 , not assigned-Cytochrome P450
Synonyms: CYP2E1, 4-nitrophenol 2-hydroxylase, CPE1, Cytochrome p450 IIe1, Cytochrome P450-J, p450C2E, p450-J, CYP2E, CYPIIE1, Cytochrome P450 2E1
Target Sequences: NM_000773 NP_000764.1 P05181

Publications (3)

1
Chitinase 3-like-1 contributes to acetaminophen-induced liver injury by promoting hepatic platelet recruitment. Zhao Shan, Leike Li, Constance Lynn Atkins, Meng Wang, Yankai Wen, Jongmin Jeong, Nicolas F Moreno, Dechun Feng, Xun Gui, Ningyan Zhang, Chun Geun Lee, Jack A Elias, William M Lee, Bin Gao, Fong Wilson Lam, Zhiqiang An, Cynthia Ju. eLife. 2021 June;10: [Full Text Article] [PubMed:34110284] [PMC:PMC8233036] Related Antibodies: LS-C6332.
2
Disrupting the TRIB3-SQSTM1 interaction reduces liver fibrosis by restoring autophagy and suppressing exosome-mediated HSC activation. Xiao-Wei Zhang, Ji-Chao Zhou, Dian Peng, Fang Hua, Ke Li, Jiao-Jiao Yu, Xiao-Xi Lv, Bing Cui, Shan-Shan Liu, Jin-Mei Yu, Feng Wang, Cai-Cai Jin, Zhao-Na Yang, Chen-Xi Zhao, Xue-Ying Hou, Bo Huang, Zhuo-Wei Hu. Autophagy. 2020 May;;16:782-796. [Full Text Article] [PubMed:31286822] [PMC:PMC7144866]
3
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Boj SF, van Es JH, Huch M, Li VS, Jos[Character e9] A, Hatzis P, Mokry M, Haegebarth A, van den Born M, Chambon P, Voshol P, Dor Y, Cuppen E, Fillat C, Clevers H. Cell. 2012 Dec;151:1595-607. [Full Text Article] [PubMed:23260145] Related Antibodies: LS-C6332.

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Proteins (12)
Over-Expression Lysate (2)
Recombinant (10)
CYP2E1 (12)
No (12)
6His, N-terminus (1)
GST (1)
GST, N-terminus (1)
His (5)
His, N-Terminal (1)
Myc-DDK (Flag) (3)
Human (7)
Mouse (3)
Rat (1)
293T Cells (1)
E. coli (6)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Yeast (1)
Purified (2)
CYP2E1 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
CYP2E1 Protein - Recombinant Cytochrome P450 2E1 By SDS-PAGE
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E. coli
His
29.4 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
CYP2E1 Protein
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Yeast
6His, N-terminus
58.67 kD
1 mg/$1,683; 100 µg/$499; 20 µg/$364
CYP2E1 Protein - Purified recombinant protein CYP2E1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
56.7 kDa
20 µg/$1,107
CYP2E1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
56.7 kDa
100 µg/$494
CYP2E1 Protein - Recombinant Cytochrome P450 2E1 By SDS-PAGE
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E. coli
His
14.6 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
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E. coli
His
14.7 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
CYP2E1 Protein - Recombinant Cytochrome P450 2E1 By SDS-PAGE
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E. coli
His
23.1 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
CYP2E1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CYP2E1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
56.7 kDa
20 µg/$150
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E. coli
His, N-Terminal
29.1kDa
10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
CYP2E1 Protein - 12.5% SDS-PAGE of human CYP2E1 stained with Coomassie Blue
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Wheat Germ Extract
GST
83.2 kDa
2 µg/$439
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).