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CYP2A6

cytochrome P450, family 2, subfamily A, polypeptide 6

This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6.

Gene Name: cytochrome P450, family 2, subfamily A, polypeptide 6
Family/Subfamily: Cytochrome P450 , not assigned-Cytochrome P450
Synonyms: CYP2A6, CYP2A, Cytochrome P450(I), CYPIIA6, p450PB, p450C2A, Coumarin 7-hydroxylase, CYP2A3, Cytochrome P450 2A6, Cytochrome P450 IIA3
Target Sequences: NM_000762 AAB40518.1 P11509

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
CYP2A6 (4)
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GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (3)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
CYP2A6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
56.3 kDa
100 µg/$710
CYP2A6 Protein - Purified recombinant protein CYP2A6 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
56.3 kDa
20 µg/$1,107
CYP2A6 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CYP2A6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
56.3 kDa
20 µg/$215
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).