CYP26B1

cytochrome P450, family 26, subfamily B, polypeptide 1

Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

CYP26B1 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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CYP26B1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101630

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58 kDa

Price:

100 µg/$494

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Human CYP26B1 Protein (Recombinant His-T7) (aa1-512) - LS-G15328

Source:

E. coli

Tag:

His-T7

Molecular Weight:

61.3 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human CYP26B1 Protein (Recombinant GST, N-terminus) (aa131-230) - LS-G62847

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CYP26B1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87731

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58 kDa

Price:

20 µg/$150

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Human CYP26B1 Protein (Recombinant GST) (Full Length) - LS-G34558

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

83.9 kDa

Price:

2 µg/$439

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