Products
Research Areas
COVID-19
Resources
Login
Quick Order
Cart Cart lightblue
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us

Locations


Orders Processing,
Shipping & Receiving,
Warehouse

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464


Production Lab

Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036

Telephone Numbers



Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

Contact Us



Additional Contact Details

Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

CYP17 / CYP17A1

cytochrome P450, family 17, subfamily A, polypeptide 1

CYP17 / CYP17A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.

Gene Name: cytochrome P450, family 17, subfamily A, polypeptide 1
Family/Subfamily: Cytochrome P450 , not assigned-Cytochrome P450
Synonyms: CYP17A1, CYP17, CYPXVII, CPT7, Cytochrome P450-C17, Cytochrome P450c17, p450C17, Steroid 17-alpha-monooxygenase, Cytochrome P450 17A1, Cytochrome p450 XVIIA1, S17AH
Target Sequences: NM_000102 NP_000093.1 P05093

Publications (7)

1
Adult granulosa cell tumors of the ovary: a retrospective study of 30 cases with respect to the expression of steroid synthesis enzymes. Kitamura S, Abiko K, Matsumura N, Nakai H, Akimoto Y, Tanimoto H, Konishi I. Journal of gynecologic oncology. 2017 28:e31. (ICC; Human) [Full Text Article] [PubMed:28541629] [PMC:PMC5447140]
2
EB 2017 Article: Soy protein isolate feeding does not result in reproductive toxicity in the pre-pubertal rat testis. Ronis MJ, Gomez-Acevedo H, Shankar K, Sharma N, Blackburn M, Singhal R, Mercer KE, Badger TM. Experimental biology and medicine (Maywood, N.J.). 2018 May;243:695-707. [Full Text Article] [PubMed:29763383] [PMC:PMC6378512]
3
Identification of Somatic Mutations in CLCN2 in Aldosterone-Producing Adenomas. Juilee Rege, Kazutaka Nanba, Amy R Blinder, Samuel Plaska, Aaron M Udager, Pankaj Vats, Chandan Kumar-Sinha, Thomas J Giordano, William E Rainey, Tobias Else. Journal of the Endocrine Society. 2020 October;4:bvaa123. [Full Text Article] [PubMed:33033789] [PMC:PMC7528565] Related Antibodies: LS-B14227.
4
Targeted Molecular Characterization of Aldosterone-Producing Adenomas in White Americans. Kazutaka Nanba, Kei Omata, Tobias Else, Peter C C Beck, Aya T Nanba, Adina F Turcu, Barbra S Miller, Thomas J Giordano, Scott A Tomlins, William E Rainey. The Journal of clinical endocrinology and metabolism. 2018 October;103:3869-3876. [Full Text Article] [PubMed:30085035] [PMC:PMC6179168] Related Antibodies: LS-B14227.
5
The Prostate Cancer Therapy Enzalutamide Compared with Abiraterone Acetate/Prednisone Impacts Motivation for Exploration, Spatial Learning and Alters Dopaminergic Transmission in Aged Castrated Mice. Celeste Nicola , Martine Dubois , Cynthia Campart , Tareq Al Sagheer , Laurence Desrues , Damien Schapman , Ludovic Galas , Marie Lange , Florence Joly , Hélène Castel. Cancers. 2021 Jul;13:3518. [Full Text Article] [PubMed:34298734] [PMC:PMC8304001] Related Antibodies: LS-C352100.
6
Prevalence of Somatic Mutations in Aldosterone-Producing Adenomas in Japanese Patients. Kazutaka Nanba, Yuto Yamazaki, Nolan Bick, Kei Onodera, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Amy R Blinder, Scott A Tomlins, William E Rainey, Fumitoshi Satoh, Hironobu Sasano. The Journal of clinical endocrinology and metabolism. 2020 November;105:e4066-e4073. [Full Text Article] [PubMed:32844168] [PMC:PMC7947976] Related Antibodies: LS-B14227.
7
Intratumoral steroid profiling of adrenal cortisol-producing adenomas by liquid chromatography- mass spectrometry. James P Teuber, Kazutaka Nanba, Adina F Turcu, Xuan Chen, Lili Zhao, Tobias Else, Richard J Auchus, William E Rainey, Juilee Rege. The Journal of steroid biochemistry and molecular biology. 2021 September;212:105924. [Full Text Article] [PubMed:34089832] [PMC:PMC8734951] Related Antibodies: LS-B14227.
more

☰ Filters
Products
Proteins (10)
Over-Expression Lysate (2)
Recombinant (8)
CYP17 / CYP17A1 (10)
No (10)
6His, N-terminus (1)
6His-SUMO, N-terminus (1)
GST (1)
GST, N-terminus (1)
His-T7 (2)
His-T7, N-terminus (1)
Myc-DDK (Flag) (3)
Human (6)
Mouse (1)
Rat (2)
293T Cells (1)
E. coli (6)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (4)
CYP17 / CYP17A1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
GST, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CYP17 / CYP17A1 Protein - Purified recombinant protein CYP17A1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
57.2 kDa
20 µg/$1,107
CYP17 / CYP17A1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CYP17 / CYP17A1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
CYP17 / CYP17A1 Protein - Recombinant 17-Alpha-Hydroxylase By SDS-PAGE
Select
E. coli
His-T7
40.6 kDa
10 µg/$271; 50 µg/$380; 100 µg/$607; 200 µg/$757; 1 mg/$1,810; 500 µg/$1,372; 5 mg/$2,768; 2 mg/$1,991
CYP17 / CYP17A1 Protein - Recombinant 17-Alpha-Hydroxylase By SDS-PAGE
Select
E. coli
His-T7
38.4 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
CYP17 / CYP17A1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
57.2 kDa
20 µg/$150
CYP17 / CYP17A1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
57.2 kDa
100 µg/$494
CYP17 / CYP17A1 Protein - Recombinant 17-Alpha-Hydroxylase (S17aH) by SDS-PAGE
Select
E. coli
His-T7, N-terminus
38.6kDa
10 µg/$271; 50 µg/$380; 200 µg/$757; 100 µg/$607; 1 mg/$1,810; 500 µg/$1,372; 5 mg/$2,768; 2 mg/$1,991
CYP17 / CYP17A1 Protein - 12.5% SDS-PAGE of human CYP17A1 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
81.62 kDa
2 µg/$439
Viewing 1-10 of 10 product results


Filtered By:
Products: Proteins


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).