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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
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CYP17 / CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
CYP17 / CYP17A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
Gene Name:
cytochrome P450, family 17, subfamily A, polypeptide 1
Adult granulosa cell tumors of the ovary: a retrospective study of 30 cases with respect to the expression of steroid synthesis enzymes. Kitamura S, Abiko K, Matsumura N, Nakai H, Akimoto Y, Tanimoto H, Konishi I. Journal of gynecologic oncology. 2017 28:e31. (ICC; Human)[Full Text Article]
[PubMed:28541629]
[PMC:PMC5447140]
2
EB 2017 Article: Soy protein isolate feeding does not result in reproductive toxicity in the pre-pubertal rat testis. Ronis MJ, Gomez-Acevedo H, Shankar K, Sharma N, Blackburn M, Singhal R, Mercer KE, Badger TM. Experimental biology and medicine (Maywood, N.J.). 2018 May;243:695-707. [Full Text Article]
[PubMed:29763383]
[PMC:PMC6378512]
3
Identification of Somatic Mutations in CLCN2 in Aldosterone-Producing Adenomas. Juilee Rege, Kazutaka Nanba, Amy R Blinder, Samuel Plaska, Aaron M Udager, Pankaj Vats, Chandan Kumar-Sinha, Thomas J Giordano, William E Rainey, Tobias Else. Journal of the Endocrine Society. 2020 October;4:bvaa123. [Full Text Article]
[PubMed:33033789]
[PMC:PMC7528565]
Related Antibodies: LS-B14227.
4
Targeted Molecular Characterization of Aldosterone-Producing Adenomas in White Americans. Kazutaka Nanba, Kei Omata, Tobias Else, Peter C C Beck, Aya T Nanba, Adina F Turcu, Barbra S Miller, Thomas J Giordano, Scott A Tomlins, William E Rainey. The Journal of clinical endocrinology and metabolism. 2018 October;103:3869-3876. [Full Text Article]
[PubMed:30085035]
[PMC:PMC6179168]
Related Antibodies: LS-B14227.
5
The Prostate Cancer Therapy Enzalutamide Compared with Abiraterone Acetate/Prednisone Impacts Motivation for Exploration, Spatial Learning and Alters Dopaminergic Transmission in Aged Castrated Mice. Celeste Nicola , Martine Dubois , Cynthia Campart , Tareq Al Sagheer , Laurence Desrues , Damien Schapman , Ludovic Galas , Marie Lange , Florence Joly , Hélène Castel. Cancers. 2021 Jul;13:3518. [Full Text Article]
[PubMed:34298734]
[PMC:PMC8304001]
Related Antibodies: LS-C352100.
6
Prevalence of Somatic Mutations in Aldosterone-Producing Adenomas in Japanese Patients. Kazutaka Nanba, Yuto Yamazaki, Nolan Bick, Kei Onodera, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Amy R Blinder, Scott A Tomlins, William E Rainey, Fumitoshi Satoh, Hironobu Sasano. The Journal of clinical endocrinology and metabolism. 2020 November;105:e4066-e4073. [Full Text Article]
[PubMed:32844168]
[PMC:PMC7947976]
Related Antibodies: LS-B14227.
7
Intratumoral steroid profiling of adrenal cortisol-producing adenomas by liquid chromatography- mass spectrometry. James P Teuber, Kazutaka Nanba, Adina F Turcu, Xuan Chen, Lili Zhao, Tobias Else, Richard J Auchus, William E Rainey, Juilee Rege. The Journal of steroid biochemistry and molecular biology. 2021 September;212:105924. [Full Text Article]
[PubMed:34089832]
[PMC:PMC8734951]
Related Antibodies: LS-B14227.
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PLEASE NOTE
For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.
The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).