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CYBA / p22phox

cytochrome b-245, alpha polypeptide

Cytochrome b is composed of cytochrome b alpha (CYBA; flavocytochrome b-558) and beta (CYBB; flavocytochrome b-245) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBA deficiency is associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.

Gene Name: cytochrome b-245, alpha polypeptide
Synonyms: CYBA, Cytochrome b(558) alpha chain, Cytochrome b-245 light chain, Cytochrome b558 subunit alpha, p22 phagocyte B-cytochrome, p22-PHOX, Cytochrome b light chain, p22phox
Target Sequences: NM_000101 NP_000092.2 P13498

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Proteins (3)
Over-Expression Lysate (2)
Recombinant (1)
CYBA / p22phox (3)
No (3)
GST (1)
Myc-DDK (Flag) (2)
Human (2)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (1)
CYBA / p22phox Protein - 12.5% SDS-PAGE of human CYBA stained with Coomassie Blue
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Wheat Germ Extract
GST
53.68 kDa
2 µg/$439
CYBA / p22phox Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
20.8 kDa
100 µg/$494
CYBA / p22phox Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
20.8 kDa
20 µg/$150
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).