CXCR2

chemokine (C-X-C motif) receptor 2

CXCR2 is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.

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Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

CXCR2 (8)

Publications

No (8)

Tag

6His-SUMO, N-terminus (1)

GST (1)

Myc-DDK (Flag) (5)

Species

Human (6)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (3)

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Human CXCR2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68095

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.6 kDa

Price:

20 µg/$1,107

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Human CXCR2 Protein (Recombinant 6His-SUMO, N-terminus) - LS-G56353

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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CXCR2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G129673

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

41.2 kDa

Price:

100 µg/$494

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Human CXCR2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81445

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.6 kDa

Price:

20 µg/$150

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Human CXCR2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81444

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

41.2 kDa

Price:

20 µg/$150

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CXCR2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99479

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.6 kDa

Price:

100 µg/$494

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Human CXCR2 Protein (Recombinant) (Met1-Leu57) - LS-G133632

Source:

E. coli

Tag:

None

Molecular Weight:

36.6kDa

Price:

10 µg/$255; 50 µg/$323; 200 µg/$562; 100 µg/$450; 1 mg/$1,480; 500 µg/$1,096; 5 mg/$2,395; 2 mg/$1,646

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Human CXCR2 Protein (Recombinant GST) (Full Length) - LS-G29040

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

67.2 kDa

Price:

10 µg/$479; 25 µg/$670

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