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CXCR2

chemokine (C-X-C motif) receptor 2

CXCR2 is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.

Gene Name: chemokine (C-X-C motif) receptor 2
Family/Subfamily: GPCR , Chemokine
Synonyms: CXCR2, CDw128b, CD182 antigen, CMKAR2, CXCR-2, CD182, CXC-R2, IL-8R B, Il-8 receptor b, IL-8 receptor type 2, Il-8rb, IL8R2, IL8RB, Interleukin-8 receptor type B, GRO/MGSA receptor, Interleukin 8 receptor beta, Interleukin 8 receptor, beta, Chemokine (CXC) receptor 2, IL8RA, Interleukin 8 receptor B, Interleukin 8 receptor type 2
Target Sequences: nm_001557 NP_001548.1 P25025

Publications (5)

1
IL-8-mediated angiogenic responses of endothelial cells to lipid antigen activation of iNKT cells depend on EGFR transactivation. Kyriakakis E, Cavallari M, Pfaff D, Fabbro D, Mestan J, Philippova M, De Libero G, Erne P, Resink TJ. Journal of leukocyte biology. 2011 90:929-39. [PubMed:21807744]
2
CXCR2 expression and postoperative complications affect long-term survival in patients with esophageal cancer. Nishi T, Takeuchi H, Matsuda S, Ogura M, Kawakubo H, Fukuda K, Nakamura R, Takahashi T, Wada N, Saikawa Y, Omori T, Kitagawa Y. World journal of surgical oncology. 2015 13:232. (IHC-P; Human) [Full Text Article] [PubMed:26231560] [PMC:PMC4522106]
3
Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-?B-Snail signaling in glioma. Zhang B, Shi L, Lu S, Sun X, Liu Y, Li H, Wang X, Zhao C, Zhang H, Wang Y. Cancer biology & therapy. 2015 16:898-911. (IHC, WB; Human) [Full Text Article] [PubMed:25870011] [PMC:PMC4623112] Related Antibodies: LS-C171552.
4
Pharmacological Blockade of Spinal CXCL3/CXCR2 Signaling by NVP CXCR2 20, a Selective CXCR2 Antagonist, Reduces Neuropathic Pain Following Peripheral Nerve Injury. Anna Piotrowska, Ewelina Rojewska, Katarzyna Pawlik, Grzegorz Kreiner, Agata Ciechanowska, Wioletta Makuch, Irena Nalepa, Joanna Mika. Frontiers in immunology. 2019 Sep;10:2198. [Full Text Article] [PubMed:31616413] [PMC:PMC6775284]
5
Clinical significance of CXCL-8/CXCR-2 network in esophageal squamous cell carcinoma. Ogura M, Takeuchi H, Kawakubo H, Nishi T, Fukuda K, Nakamura R, Takahashi T, Wada N, Saikawa Y, Omori T, Miyasho T, Yamada S, Kitagawa Y. Surgery. 2013 Sep;154:512-20. [Full Text Article] [PubMed:23972657] Related Antibodies: LS-A803.
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Proteins (8)
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CXCR2 (8)
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6His-SUMO, N-terminus (1)
GST (1)
Myc-DDK (Flag) (5)
Human (6)
293T Cells (2)
E. coli (2)
HEK 293 Cells (3)
Wheat Germ Extract (1)
Purified (3)
CXCR2 Protein - Purified recombinant protein CXCR2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
40.6 kDa
20 µg/$1,107
CXCR2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
CXCR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
41.2 kDa
100 µg/$494
CXCR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
40.6 kDa
20 µg/$150
CXCR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
41.2 kDa
20 µg/$150
CXCR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
40.6 kDa
100 µg/$494
CXCR2 Protein - Recombinant Interleukin 8 Receptor Beta (IL8Rb) by SDS-PAGE
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E. coli
None
36.6kDa
10 µg/$255; 50 µg/$323; 200 µg/$562; 100 µg/$450; 1 mg/$1,480; 500 µg/$1,096; 5 mg/$2,395; 2 mg/$1,646
CXCR2 Protein - 12.5% SDS-PAGE of human CXCR2 stained with Coomassie Blue
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Wheat Germ Extract
GST
67.2 kDa
10 µg/$479; 25 µg/$670
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).