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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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CXCL1 / GRO Alpha

chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

GRO Alpha (CXCL1), a small cytokine belonging to the CXC chemokine family, secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. GRO alpha is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. GRO Alpha plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis. This chemokine elicits its effects by signaling through the chemokine receptor CXCR2. An initial study in mice showed evidence that GRO alpha decreased the severity of multiple sclerosis and may offer a neuro-protective function.

Gene Name: chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
Family/Subfamily: Intercrine , Intercrine alpha
Synonyms: CXCL1, C-X-C motif chemokine 1, Fibroblast secretory protein, FSP, GRO1, GROa, Growth-regulated alpha protein, GRO-alpha(1-73), MGSA, MGSA-a, Small inducible cytokine b1, GRO, MGSA alpha, NAP-3, SCYB1
Target Sequences: NM_001511 NP_001502.1 P09341

Publications (3)

1
Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFa-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, Usami I, Sakamoto S, Abe H, Watanabe T, Yamori T, Shibasaki M, Nomoto A. PloS one. 2015 10:e0119415. (IHC; Human) [Full Text Article] [PubMed:25785838] [PMC:PMC4364666] Related Antibodies: LS-C104351.
2
Developmental regulation of the neuroinflammatory responses to LPS and/or hypoxia-ischemia between preterm and term neonates: An experimental study. Brochu ME, Girard S, Lavoie K, Sébire G. Journal of neuroinflammation. 2011 8:55. (WB; Rat) [Full Text Article] [PubMed:21599903]
3
3'-Sialyllactose as an inhibitor of p65 phosphorylation ameliorates the progression of experimental rheumatoid arthritis. Kang LJ, Kwon ES, Lee KM, Cho C, Lee JI, Ryu YB, Youm TH, Jeon J, Cho MR, Jeong SY, Lee SR, Kim W, Yang S. British journal of pharmacology. 2018 December;175:4295-4309. [Full Text Article] [PubMed:30152858] [PMC:PMC6240131]

Filtered by: None
Target
CXCL1 / GRO Alpha (154)
Reactivity
Human (62)
Mouse (52)
Rat (53)
Bat (1)
Bovine (1)
Chimpanzee (3)
Horse (1)
Monkey (1)
Pig (5)
Rabbit (1)
Sheep (1)
Application
IHC (16)
IHC-P (5)
WB (138)
ELISA (59)
Func (1)
ICC (2)
IF (1)
Inhb (1)
IP (3)
Neut (15)
Peptide-ELISA (2)
Host
rabbit (115)
mouse (38)
goat (1)
Isotype
IgG (66)
IgG1 (2)
IgG1,k (7)
IgG2a,k (1)
IgG2b,k (8)
IgM (1)
Clonality
monoclonal mc (38)
polyclonal pc (116)
Clone
2A9 (1)
2D7 (1)
6G2 (1)
7A11 (1)
Format
AP Conjugated (7)
APC (8)
APC Conjugated (13)
Biotin Conjugated (21)
Cy3 Conjugated (8)
Cy7 Conjugated (8)
FITC Conjugated (18)
HRP Conjugated (17)
PE Conjugated (15)
Unconjugated (47)
Epitope
aa25-96 (32)
aa35-107 (8)
C-Terminus (5)
N-Terminus (3)
aa36-107 (3)
Internal (1)
Pro88 (1)
aa39-88 (1)
aa98-107 (1)
aa99-107 (1)
Publications
No (153)
Yes (1)
Showing 1-25 of 154 results

IHC-plus™ CXCL1 / GRO Alpha Antibody LS-B2843
Rabbit Polyclonal to Human CXCL1 / GRO Alpha
Human
ELISA, IHC, IHC-P, Neut, WB
Unconjugated
100µg 1mg/ml  $485.00
Anti-GRO Alpha antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

CXCL1 / GRO Alpha Antibody LS-C104351
Publications (1)
Publications (1)
Rabbit Polyclonal to Human CXCL1 / GRO Alpha
Human
ELISA, WB
Unconjugated
50µg  $285.00; 100µg  $325.00
Western Blot (non-reducing) of GRO / CXCL1 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western Blot (reducing) of GRO / CXCL1 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.

CXCL1 / GRO Alpha Antibody (aa36-107, clone 7A11) LS-C125418
Mouse Monoclonal [clone 7A11] (IgG) to Human CXCL1 / GRO Alpha
Human
ELISA, WB
Unconjugated
100µg  $590.00

CXCL1 / GRO Alpha Antibody LS-C48831
Rabbit Polyclonal to Rat CXCL1 / GRO Alpha
Mouse, Rat
IHC, IP, WB
Unconjugated
100µg  $465.00
Western blot of GRO / CXCL1 antibody.

CXCL1 / GRO Alpha Antibody (Pro88) LS-C177218
Rabbit Polyclonal to Human CXCL1 / GRO Alpha
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
100µl  $345.00
IHC of GRO (P88) pAb at 1:50 in paraffin-embedded human brain tissue.

CXCL1 / GRO Alpha Antibody LS-C104778
Rabbit Polyclonal to Rat CXCL1 / GRO Alpha
Rat
ELISA, WB
Unconjugated
50µg  $285.00; 100µg  $325.00
Western Blot (non-reducing) of GRO / CXCL1 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western Blot (reducing) of GRO / CXCL1 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.

CXCL1 / GRO Alpha Antibody (Biotin) LS-C104777
Rabbit Polyclonal to Rat CXCL1 / GRO Alpha
Rat
ELISA, WB
Biotin Conjugated
25µg  $285.00; 50µg  $325.00
Western Blot (non-reducing) of GRO / CXCL1 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western Blot (reducing) of GRO / CXCL1 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.

CXCL1 / GRO Alpha Antibody (clone 2D7) LS-C139335
Mouse Monoclonal [clone 2D7] (IgG2a,k) to Human CXCL1 / GRO Alpha
Human
ELISA
Unconjugated
100µg  $365.00
Detection limit for recombinant GST tagged CXCL1 is 1 ng/ml as a capture antibody.

IHC-plus™ CXCL1 / GRO Alpha Antibody (Internal) LS-B14347
Rabbit Polyclonal (IgG) to Human CXCL1 / GRO Alpha
Mouse, Rat, Human
ELISA, IHC, IHC-P
Unconjugated
50µl 1mg/ml  $425.00
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

CXCL1 / GRO Alpha Antibody LS-C104609
Rabbit Polyclonal to Mouse CXCL1 / GRO Alpha
Mouse
ELISA, WB
Unconjugated
50µg  $285.00; 100µg  $325.00
Western Blot (non-reducing) of GRO / CXCL1 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western Blot (reducing) of GRO / CXCL1 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.

CXCL1 / GRO Alpha Antibody (Biotin) LS-C104613
Rabbit Polyclonal to Mouse CXCL1 / GRO Alpha
Mouse
ELISA, WB
Biotin Conjugated
25µg  $285.00; 50µg  $325.00
Western Blot (non-reducing) of GRO / CXCL1 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western Blot (reducing) of GRO / CXCL1 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.

CXCL1 / GRO Alpha Antibody (aa36-107) LS-C137618
Mouse Monoclonal (IgG1) to Human CXCL1 / GRO Alpha
Human
ELISA, WB
Unconjugated
100µl 1mg/ml  $385.00
Western blot Image

CXCL1 / GRO Alpha Antibody LS-C212186
Rabbit Polyclonal (IgG) to Mouse CXCL1 / GRO Alpha
Mouse
ELISA, WB
Unconjugated
50µg  $285.00; 100µg 1mg/ml  $385.00

CXCL1 / GRO Alpha Antibody (HRP) LS-C212191
Rabbit Polyclonal (IgG) to Mouse CXCL1 / GRO Alpha
Mouse
ELISA, IHC, WB
HRP Conjugated
50µg  $285.00; 100µg  $385.00

CXCL1 / GRO Alpha Antibody (Biotin) LS-C212194
Rabbit Polyclonal (IgG) to Mouse CXCL1 / GRO Alpha
Mouse
ELISA, IHC, WB
Biotin Conjugated
50µg  $285.00; 100µg  $385.00

CXCL1 / GRO Alpha Antibody (FITC) LS-C212195
Rabbit Polyclonal (IgG) to Mouse CXCL1 / GRO Alpha
Mouse
ELISA, WB
FITC Conjugated
50µg  $285.00; 100µg  $385.00

CXCL1 / GRO Alpha Antibody (HRP) LS-C546503
Rabbit Polyclonal (IgG) to Human CXCL1 / GRO Alpha
Human
ELISA, Neut, WB
HRP Conjugated
100µl  $545.00

CXCL1 / GRO Alpha Antibody (HRP) LS-C541665
Mouse Monoclonal (IgG1,k) to Human CXCL1 / GRO Alpha
Human
ELISA, WB
HRP Conjugated
100µl  $710.00

CXCL1 / GRO Alpha Antibody (Biotin) LS-C521532
Mouse Monoclonal (IgG1,k) to Human CXCL1 / GRO Alpha
Human
ELISA, WB
Biotin Conjugated
100µl  $710.00

CXCL1 / GRO Alpha Antibody LS-C801478
Rabbit Polyclonal (IgG) to Human CXCL1 / GRO Alpha
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Immunofluorescence Image

CXCL1 / GRO Alpha Antibody (aa25-96, Biotin) LS-C683790
Rabbit Polyclonal to Mouse CXCL1 / GRO Alpha
Mouse
WB
Biotin Conjugated
100µl 0.5mg/ml  $245.00; 200µl 0.5mg/ml  $285.00; 1ml 0.5mg/ml  $475.00
Western blot of GRO / CXCL1 antibody.

CXCL1 / GRO Alpha Antibody (N-Terminus) LS-C193999
Rabbit Polyclonal (IgG) to Mouse CXCL1 / GRO Alpha
Mouse
IHC, IHC-P, WB
Unconjugated
100µg 1ml  $860.00

CXCL1 / GRO Alpha Antibody LS-C665997
Rabbit Polyclonal (IgG) to Human CXCL1 / GRO Alpha
Human
ELISA, IHC, WB
Unconjugated
100µg  $335.00

CXCL1 / GRO Alpha Antibody LS-C193997
Rabbit Polyclonal (IgG) to Mouse CXCL1 / GRO Alpha
Mouse
IHC, WB
Unconjugated
500µg 1ml  $860.00

CXCL1 / GRO Alpha Antibody LS-C193998
Rabbit Polyclonal (IgG) to Mouse CXCL1 / GRO Alpha
Mouse
IHC, WB
Unconjugated
100µg 1ml  $860.00
Showing 1-25 of 154 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).