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CX3CL1/fractalkine is a chemokine with a unique CX3C motif. Fractalkine is synthesized in endothelial cells as a membrane protein, and the N-terminal domain containing a CX3C motif is cleaved and secreted. Fractalkine is the first described cell-surface anchored chemokine and has potent mononuclear cell-directed adhesion and chemotactic properties. Fractalkine is involved in the pathogenesis of various chronic inflammatory diseases, such as rheumatoid arthritis and atherosclerosis.
Gene Name: | chemokine (C-X3-C motif) ligand 1 |
Family/Subfamily: | Intercrine , Intercrine delta |
Synonyms: | CX3CL1, ABCD-3, C-X3-C motif chemokine 1, C3Xkine, Chemokine ntt, CXC3C, FKN, Fractalkine, Neurotactin, CXC3, NTN, SCYD1, Small-inducible cytokine D1 |
Target Sequences: | NM_002996 NP_002987.1 P78423 |
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