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Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay.
Gene Name: | CWC22 spliceosome-associated protein homolog (S. cerevisiae) |
Synonyms: | CWC22, EIF4GL, KIAA1604, NCM, Nucampholin homolog, FSAPb |
Target Sequences: | Q9HCG8 Q9HCG8 |
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