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CUX1 / CASP
cut-like homeobox 1
Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator.
| Gene Name: | cut-like homeobox 1 |
| Synonyms: | CUX1, CASP, CDP1, Clox, COY1, CUTL1, CCAAT displacement protein, Cut homolog, CUX, CUT, GOLIM6, Homeobox protein cux-1, p100, p200, p75, Protein CASP, CDP, Cut-like homeobox 1, Nbla10317, p110 |
| Target Sequences: | NM_001913 NP_001904.2 Q13948 |
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