Cullin 4A / CUL4A

cullin 4A

Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL.

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Products

Proteins (7)

Type

Over-Expression Lysate (4)

Recombinant (3)

Target

Cullin 4A / CUL4A (7)

Publications

No (7)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (5)

Species

Human (5)

Source

293T Cells (2)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human Cullin 4A / CUL4A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87334

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

87.5 kDa

Price:

20 µg/$215

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Human Cullin 4A / CUL4A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87335

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

87.68 kDa

Price:

20 µg/$150

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Cullin 4A / CUL4A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117215

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

87.68 kDa

Price:

100 µg/$494

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Human Cullin 4A / CUL4A Protein (Recombinant GST) (Full Length) - LS-G31161

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

114.1 kDa

Price:

2 µg/$439

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Human Cullin 4A / CUL4A Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70523

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

76.6 kDa

Price:

20 µg/$1,107

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Human Cullin 4A / CUL4A Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G60727

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Cullin 4A / CUL4A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99273

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

87.5 kDa

Price:

100 µg/$710

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