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CUL9 / Cullin 9

cullin 9

Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).

Gene Name:	cullin 9
Synonyms:	CUL9, Cullin 9, Cullin-9, CUL-9, H7AP1, RP3-330M21.2, KIAA0708, PARC, UbcH7-associated protein 1
Target Sequences:	NP_055904.1 Q8IWT3

Publications (2)

Parc: a cytoplasmic anchor for p53. Nikolaev AY, Li M, Puskas N, Qin J, Gu W. Cell. 2003 112:29-40. [PubMed:12526791] Related Antibodies: LS-B401.

Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage. Cai X, Liu X. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:16958-63. [PubMed:18952844] [PMC:PMC2579360] Related Antibodies: LS-B3911.

Human CUL9 / Cullin 9 (Sandwich ELISA) ELISA Kit - LS-F9397

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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