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CUL5 / Cullin-5
cullin 5
Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.
| Gene Name: | cullin 5 |
| Family/Subfamily: | Ion Channel |
| Synonyms: | CUL5, Cullin 5, CUL-5, VACM-1, VACM1, Cullin-5 |
| Target Sequences: | NM_003478 NP_003469.2 Q93034 |
Publications (2)
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