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Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.
Gene Name: | CUE domain containing 2 |
Synonyms: | CUEDC2, BA18I14.5, C10orf66, CUE domain containing 2 |
Target Sequences: | NM_024040 NP_076945.2 Q9H467 |
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