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CTSD / Cathepsin D
cathepsin D
CTSD / Cathepsin D is a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. In Chinese hamster the protein Cathepsin D is encoded by the gene H671_3g9701 (Uniprot G3I4W7).
| Gene Name: | cathepsin D |
| Family/Subfamily: | Protease , Aspartic A1 |
| Synonyms: | CTSD, CPSD, CLN10, Lysosomal aspartyl peptidase, Lysosomal aspartyl protease, ProCathepsin D, CatD, Cathepsin D |
| Target Sequences: | NM_001909 NP_001900.1 P07339 |
Publications (2)
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