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CTSD / Cathepsin D

cathepsin D

CTSD / Cathepsin D is a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. In Chinese hamster the protein Cathepsin D is encoded by the gene H671_3g9701 (Uniprot G3I4W7).

Gene Name: cathepsin D
Family/Subfamily: Protease , Aspartic A1
Synonyms: CTSD, CPSD, CLN10, Lysosomal aspartyl peptidase, Lysosomal aspartyl protease, ProCathepsin D, CatD, Cathepsin D
Target Sequences: NM_001909 NP_001900.1 P07339

Publications (2)

1
Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aß and tau pathology. Perez SE, He B, Nadeem M, Wuu J, Ginsberg SD, Ikonomovic MD, Mufson EJ. Journal of neuropathology and experimental neurology. 2015 74:345-58. (WB; Human) [Full Text Article] [PubMed:25756588] [PMC:PMC4366294]
2
Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence. Lenain C, Gusyatiner O, Douma S, van den Broek B, Peeper DS. Carcinogenesis. 2015 November;36:1263-1274. [Full Text Article] [PubMed:26354777]

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Products
ELISA Kits (38)
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Custom (6)
Sandwich (25)
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CTSD / Cathepsin D (38)
Human (11)
Mouse (9)
Rat (6)
Bovine (1)
Chicken (2)
Cow (1)
Dog (1)
Guinea pig (1)
Monkey (1)
Pig (1)
Porcine (1)
Rabbit (1)
Sheep (1)
12 x 8-Well Microstrips (3)
96-Well Microplate (6)
96-Well Strip Plate (29)
No (38)
Ascites (1)
Cell Culture Supernatants (6)
Cell Lysates (1)
Plasma (27)
Serum (27)
Tissue Homogenates (9)
CTSD / Cathepsin D ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Mouse
2.74 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$990
CTSD / Cathepsin D ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$856
CTSD / Cathepsin D ELISA Kit
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Sandwich
96-Well Microplate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$718
CTSD / Cathepsin D ELISA Kit
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Sandwich
96-Well Microplate
Mouse
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$795
CTSD / Cathepsin D ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
46.88 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$798
CTSD / Cathepsin D ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$685
CTSD / Cathepsin D ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CTSD / Cathepsin D ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
46.875 - 3000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CTSD / Cathepsin D ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CTSD / Cathepsin D ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CTSD / Cathepsin D ELISA Kit
Select
Sandwich
96-Well Strip Plate
Sheep
23.438 - 1500 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$760
CTSD / Cathepsin D ELISA Kit
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Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$929
CTSD / Cathepsin D ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
CTSD / Cathepsin D ELISA Kit
Select
Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$929
CTSD / Cathepsin D ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
CTSD / Cathepsin D ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
CTSD / Cathepsin D ELISA Kit
Select
Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$783
CTSD / Cathepsin D ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Rat
7.813 - 500 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
CTSD / Cathepsin D ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$717
CTSD / Cathepsin D ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
15.625 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
CTSD / Cathepsin D ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
12.5 - 800 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
CTSD / Cathepsin D ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CTSD / Cathepsin D ELISA Kit
Select
Sandwich
96-Well Microplate
Human
46.875 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CTSD / Cathepsin D ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
46.88 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$866
CTSD / Cathepsin D ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).