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CTP Synthetase 2 / CTPS2
CTP synthase 2
CTP Synthetase 2 / CTPS2 catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants.
| Gene Name: | CTP synthase 2 |
| Synonyms: | CTPS2, CTP synthase 2, CTP synthase II, CTP synthetase isoform, CTP synthetase type 2, UTP-ammonia ligase, CTP synthetase 2, UTP--ammonia ligase 2 |
| Target Sequences: | NM_019857 NP_062831.3 Q9NRF8 |
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