Shipping & Receiving,
2 Shaker Rd Suites
Shirley, MA 01464
Floor 6, Suite 610/620
20700 44th Avenue W
Lynnwood, WA 98036
Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function.
|Gene Name:||cystathionase (cystathionine gamma-lyase)|
|Synonyms:||CTH, Cysteine-protein sulfhydrase, Cysteine desulfhydrase, Cystathionine gamma-lyase, Homoserine dehydratase, Gamma-cystathionase, Homoserine deaminase|
|Target Sequences:||NM_001902 NP_001893.2 P32929|
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.